Does the lipid membrane composition of arsonoliposomes affect their anticancer activity? A cell culture study

Molecular Nutrition & Food Research
Paraskevi ZaganaSophia G Antimisiaris

Abstract

Sonicated arsonoliposomes were prepared using arsonolipid with palmitic acid acyl chain (C16), mixed with phosphatidylcholine (PC)-based or 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based, and cholesterol (Chol) with C16/DSPC/Chol 8:12:10 molar ratio. PEG-lipid (1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated to polyethylenoglycol 2000) containing vesicles (PEGylated-arsonoliposomes; PC-based and DSPC-based) were also prepared. The cytotoxicity of these arsonoliposomes towards different cancer cells (human promyelocytic leukaemia NB4, Prostatic cancer PC3, human breast adenocarcinoma MDA-MB-468, human T-lymphocyte (MT-4) and also towards human umbilical vein endothelial cells (HUVECs) was evaluated by calculating the arsonoliposome-induced growth inhibition of the cells by the MTT assay. IC-50 values were interpolated from cell number/arsonoliposome concentration curves. The results reveal that all types of arsonoliposomes evaluated significantly inhibit the growth of most of the cancer cells studied (PC3, NB4, MT4) with the exception of the MDA-MB-468 breast cancer cells which were minimally affected by arsonoliposomes; in some cases even less than HUVEC. Nevertheless, for the same cell type the differences ...Continue Reading

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Jul 4, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paraskevi ZaganaS G Antimisiaris
Aug 11, 2007·International Journal of Pharmaceutics·Paraskevi ZaganaSophia G Antimisiaris

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Citations

Jun 3, 2010·Drug Development and Industrial Pharmacy·Wenjuan CongGuoan Luo
May 29, 2018·Macromolecular Rapid Communications·Joji TanakaPaul Wilson

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