PMID: 3889840Feb 25, 1985

Does the 'non-coding' strand code?

Nucleic Acids Research
P M Sharp

Abstract

The hypothesis that DNA strands complementary to the coding strand contain in phase coding sequences has been investigated. Statistical analysis of the 50 genes of bacteriophage T7 shows no significant correlation between patterns of codon usage on the coding and non-coding strands. In Bacillus and yeast genes the correlation observed is not different from that expected with random synonymous codon usage, while a high correlation seen in 52 E. coli genes can be explained in terms of an excess of RNY codons. A deficiency of UUA, CUA and UCA codons (complementary to termination) seems to be restricted to the E. coli genes, and may be due to low abundance of the relevant cognate tRNA species. Thus the analysis shows that the non-coding strand has the properties expected of a sequence complementary to a coding strand, with no indications that it encodes, or may have encoded, proteins.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P K Keese, A Gibbs
May 25, 1994·Nucleic Acids Research·E MerinoF Bolívar
Nov 1, 1993·Yeast·A T Lloyd, P M Sharp
Feb 24, 2006·Virus Research·Duncan J McGeochAndrew J Davison
Jul 15, 2016·FEMS Microbiology Letters·Jose F Garcia-Mazcorro, Jose R Barcenas-Walls

Citations

Nov 1, 1966·Journal of Theoretical Biology·P H Sneath
May 22, 1970·Science·B Clarke
Mar 14, 1970·Nature·R C Richmond
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G Pieczenik
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·T Ikemura, H Ozeki
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J C Shepherd
Mar 12, 1984·Nucleic Acids Research·C Alff-Steinberger
Nov 25, 1982·Nucleic Acids Research·M Gouy, C Gautier
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T Miyata, H Hayashida
Jan 11, 1980·Nucleic Acids Research·R GranthamA Pavé
Mar 25, 1981·Nucleic Acids Research·A CasinoV Scarlato
Jan 1, 1982·Journal of Molecular Evolution·G B Golding, C Strobeck
Jan 10, 1981·Nucleic Acids Research·R GranthamR Mercier
Jul 16, 1981·Nature·W H LiM Nei

Related Concepts

MT-TA gene
DNA, Viral
Triplet Codon-amino Acid Adaptor Activity
Genes, Viral
Transfer RNA
Sense Codon
Bacteriophage T7
Codon Genus
Codon (Nucleotide Sequence)
Genes, Fungal

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