Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?

Journal of Thyroid Research
Clebson Pantoja PimentelLuiz Carlos Santana-da-Silva

Abstract

Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing. Results. More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the e...Continue Reading

References

Jan 1, 1989·Journal of Medical Genetics·J S BamforthP S Harper
Dec 1, 1996·The Journal of Clinical Endocrinology and Metabolism·N de RouxE Milgrom
May 20, 1998·Nature Genetics·A MansouriP Gruss
Aug 11, 1998·Nature Genetics·M De FeliceR Di Lauro
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·C VilainG Vassart
Aug 24, 2004·Thyroid : Official Journal of the American Thyroid Association·Massimo TonaccheraAldo Pinchera
Oct 7, 2004·Endocrine Reviews·Mario De Felice, Roberto Di Lauro
Dec 8, 2004·Developmental Biology·Rosanna ParlatoMario De Felice
May 27, 2005·Current Opinion in Genetics & Development·Andrea Albrecht, Stefan Mundlos
Sep 10, 2005·Endocrinology·Elena AmendolaMario De Felice
Jan 19, 2006·The Journal of Clinical Endocrinology and Metabolism·Monica DenticePaolo Emidio Macchia
Feb 17, 2006·Molecular Human Reproduction·Wendy J WatkinsAndrew N Shelling
Jun 6, 2006·Forensic Science International : Synergy·Elzemar Martins Ribeiro RodriguesSidney Emanuel Batista dos Santos
Aug 3, 2006·The Journal of Clinical Endocrinology and Metabolism·I BarisE Battaloglu
Feb 24, 2007·Journal of Endocrinological Investigation·L SantarpiaS Benvenga
May 11, 2010·Hormone Research in Pædiatrics·Mireille Castanet, Michel Polak
Sep 19, 2014·Endocrine Development·Guy Van Vliet, Johnny Deladoëy
Aug 28, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Ari J Wassner, Rosalind S Brown
Nov 17, 2016·Oncotarget·Martyn BullockRoderick J Clifton-Bligh
Jun 19, 2017·Best Practice & Research. Clinical Gastroenterology·Annemiek A van der EijkRobert A de Man
Jun 22, 2017·Development·Mikael Nilsson, Henrik Fagman

❮ Previous
Next ❯

Citations

Mar 3, 2021·Endocrine·Athanasia StoupaAurore Carré

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved