Does the presence of sentinel lymph node macrometastases in breast cancer patients require axillary lymph node dissection?-Single-center analysis

The Breast Journal
Tomasz NowikiewiczAgnieszka Kołacińska

Abstract

According to the current guidelines on treatment of breast cancer patients, identification of metastases in the sentinel lymph node (SLN (+)) is not an absolute indication for necessary axillary lymph node dissection (ALND). In our study, we present long-term outcomes of treatment among SLN(+) patients referred for conservative treatment, for example, no further ALND. A total of 3145 breast cancer patients subjected to sentinel lymph node biopsy (SLNB) between November 2008 and June 2015. SLN metastases were identified in 719 patients (22.9%). Locoregional recurrences and distant metastases as endpoints were distinquished. The mean follow-up time for patients after ALND was 36.2 months (6-74 months); 18.8 months (6-38 months) for patients with SLN macrometastases without ALND; and 34.0 months (6-74 months) for patients with micrometastases. Adjuvant ALND was performed in 626 of SLN(+) patients. Conservative treatment was applied in the remaining 93 cases. Among SLN(+) patients without adjuvant ALND, there was one case of recurrence (1.07%). In the group of patients without SLN, metastases recurrence was noted in 32 patients (1.32%). Among SLN(+) patients diagnosed with macrometastases, recurrence concerned 2.01% of analyzed cas...Continue Reading

References

Feb 2, 2006·CA: a Cancer Journal for Clinicians·S Eva Singletary, James L Connolly
Feb 10, 2011·JAMA : the Journal of the American Medical Association·Armando E GiulianoMonica Morrow
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 1, 2012·Annals of Surgical Oncology·Abigail S CaudleElizabeth A Mittendorf
Mar 16, 2013·The Lancet Oncology·Viviana GalimbertiUNKNOWN International Breast Cancer Study Group Trial 23-01 investigators
May 6, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A S CoatesUNKNOWN Panel Members
May 20, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C BonneauR Rouzier
Apr 21, 2016·The Breast Journal·Emma GannanUNKNOWN Melbourne Breast Group
Jun 7, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N C VerheuvelR M H Roumen

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