Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients

Journal of Surgical Oncology
Simone FamularoFabrizio Romano

Abstract

The impact of the Pringle maneuver (PM) on long-term outcome after curative resection for hepatocellular carcinoma (HCC) is controversial, with eastern series reporting conflicting results. We aim to evaluate the impact of the PM in a western cohort. We retrospectively analyzed patients with HCC who underwent liver resection between January 2001 and August 2015. Patients were divided in two groups based the use of the PM during resection. Primary outcomes were overall survival (OS) and disease-free survival (DFS). A total of 441 patients were analyzed. Of these, 176 patients (39.9%) underwent PM. Median OS was 46.4 months (95%CI: 34.1-58.7) for the PM group and 56.5 months (95%CI: 37.1-75.9) for the no-PM group (P = 0.188), with a median DFS of 26.7 months (95%CI: 15.7-37.7) and 24.9 months (95%CI: 18.1-31.7), respectively (P = 0.883). These results suggest that PM does not increase the risk of tumor recurrence or decrease long-term survival.

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Citations

Feb 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Simone FamularoLuciano De Carlis
Jan 23, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simone FamularoFabrizio Romano
Jun 3, 2020·Scientific Reports·Mohammed Al-SaeediArianeb Mehrabi
Nov 16, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Long-Hai FengZhao-You Tang
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Jan 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simone FamularoLuciano De Carlis
Dec 7, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Wong Hoi SheTan To Cheung

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