Does the proliferation fraction help identify mature B cell lymphomas with double- and triple-hit translocations?

Emarene Mationg-KalawSoo Yong Tan


The entity 'B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL)' refers to B cell neoplasms that share overlapping characteristics of BL and DLBCL. A subset of these 'grey-zone lymphomas' possesses C-MYC and IGH translocations but, in addition, contains additional rearrangements of BCL2 and/or BCL6 genes. The aim of this study was to investigate if the proliferation fraction by Ki67 immunostaining can be used to identify such double-/triple-hit lymphomas. We studied 492 cases of mature aggressive B cell neoplasms by histology, immunohistochemistry and interphase fluorescence in-situ hybridization (FISH) using break-apart probes against C-MYC, BCL2, BCL6, IGH, MALT1, PAX5 and CCND1. Forty Burkitt lymphomas and 28 cases of MYC(+) double-/triple-hit lymphomas were identified. Of the latter, 77% and 54% displayed proliferation fractions exceeding 75% and 90%, respectively. With a cut-off of >75% by Ki67 immunostaining, the sensitivity and specificity for detection of MYC(+) double/triple translocations was 0.77 and 0.36. Raising the proliferation fraction criterion to >90% improved the specificity to 0.62 at the expense of a low sensitivity of 0.54. Imm...Continue Reading


Feb 26, 2004·International Journal of Hematology·Chiyoko UedaHitoshi Ohno
Jun 9, 2006·The New England Journal of Medicine·Michael HummelMolecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe
Aug 14, 2008·Haematologica·Itziar SalaverriaLeukemia and Lymphoma Molecular Profiling Project (LLMPP)


Jul 31, 2013·Current Hematologic Malignancy Reports·Pei Lin, L Jeffrey Medeiros
Sep 1, 2013·Surgical Pathology Clinics·Lauren B Smith, Eric D Hsi
Dec 23, 2014·British Journal of Haematology·Chan Yoon CheahFrancesco Turturro
Jan 3, 2015·Archives of Pathology & Laboratory Medicine·Dennis P O'MalleyLawrence M Weiss
Jun 9, 2016·Advances in Anatomic Pathology·Penelope KorkolopoulouMaria Ioannou
Nov 4, 2016·Annals of Diagnostic Pathology·Yalda B NaeiniDennis P O'Malley
Feb 12, 2014·American Journal of Clinical Pathology·Nathan D Montgomery, Yuri Fedoriw
Jun 15, 2017·The American Journal of Surgical Pathology·Erika M MooreSteven H Swerdlow
Oct 27, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Anurag MehtaAnurag Sharma

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Jonathan W Said
Cancer Genetics and Cytogenetics
Cristina MotllóFuensanta Millá
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Adam C SeegmillerWeina Chen
© 2021 Meta ULC. All rights reserved