Does the Right Focal Variant of Alzheimer's Disease Really Exist? A Literature Analysis

Journal of Alzheimer's Disease : JAD
Carlo AbbateMatteo Cesari

Abstract

Alzheimer's disease (AD) is a clinically heterogeneous disease. Multiple atypical syndromes, distinct from the usual amnesic phenotype, have been described. In this context, the existence of a right variant of AD (RAD), characterized by enduring visuospatial impairment associated with right-sided asymmetric brain damage, has been proposed. However, to date, this phenotype remains controversial. In particular, its peculiar characteristics and the independence from more prevalent cases (especially the posterior cortical atrophy syndrome) have to be demonstrated. To explore the existence of focal RAD on the basis of existing literature. We performed a literature search for the description of atypical AD presentations, potentially evoking cases of focal RAD. To be considered as affected by RAD, the described cases had to present: 1) well documented right-sided asymmetry at neuroimaging; 2) predominant cognitive deficits localizable on the right hemisphere; 3) no specific diagnosis of a known variant of AD. Twenty-one cases were found in the literature, but some of them were subsequently excluded because some features of a different clinical syndrome were overlapped with the clinical features of RAD. Thirteen positive cases, three o...Continue Reading

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Citations

May 3, 2020·Aging Clinical and Experimental Research·Carlo AbbateMatteo Cesari
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Oleg YersteinMario F Mendez

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