Does the time of onset of severe sepsis in a surgical intensive care unit influence mortality rates: a single-center retrospective analysis

Journal of Critical Care
Suzana M LoboYasser Sakr

Abstract

The purpose of this study was to investigate possible differences in characteristics and mortality rates between early- and late-onset severe sepsis in surgical intensive care unit (ICU) patients. Prospectively collected data from all adult patients (>18 years) admitted to our 50-bed surgical ICU between 1st March 2004 and 30th July 2006 were analyzed retrospectively. Of 5925 patients admitted during the study period, 234 patients (3.9%) had severe sepsis: 74 (31.6%) early onset and 160 (68.4%) late onset. Respiratory infections (48.1 versus 27.0%, P = .002) and infections of unknown origin (21.9 versus 12.2%, P = .005) were recorded more frequently in patients with late-onset than in those with early-onset severe sepsis; abdominal infections were more frequent in early-onset than in late-onset severe sepsis (20.3% versus 7.5%, P = .005). Gram-positive infections were more frequent in late-onset than in early-onset severe sepsis (63.1 versus 51.4%, P = .036). The time of onset of severe sepsis was not independently associated with an increased risk of ICU (early versus late: odds ratio, 1.1; confidence interval, 0.78-0.59; P = .786) or in-hospital (early versus late: odds ratio, 0.68; 95% confidence interval, 0.36-1.29; P = .68...Continue Reading

References

Apr 20, 1999·JAMA : the Journal of the American Medical Association·P J PronovostE Bass
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Jul 14, 2004·Chest·Oscar Roman-MarchantJean-Louis Vincent
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Dec 20, 2007·Shock·Yasser SakrKonrad Reinhart
Dec 4, 2008·Critical Care Medicine·Claudio M MartinUNKNOWN STAR Registry Investigators

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Citations

Feb 18, 2016·Journal of Intensive Care Medicine·Christine A Motzkus, Roger Luckmann
May 10, 2020·Critical Care : the Official Journal of the Critical Care Forum·Julie A StortzFrederick A Moore

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