Does the United States Pharmacopeia throat introduce de-agglomeration of carrier-free powder from inhalers?

Pharmaceutical Research
Patricia TangHak-Kim Chan

Abstract

We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Aerosols emitting from a range of DPIs (Spinhaler®, Turbuhaler® and Osmohaler™) and induction ports (USP throat, straight tube, Alberta idealized mouth-throat geometry (AG)) were sized by laser diffraction. Total drug recovery was obtained by HPLC and fine particle fraction computed. Air flow patterns were simulated using Computational Fluid Dynamics (CFD). The straight tube did not de-agglomerate emitted powder. However, the USP throat and AG further de-agglomerated powders from the Spinhaler, but not the Turbuhaler and Osmohaler. While budesonide powder deposited similarly in all induction ports, deposition was significantly higher in the AG for both DSCG and mannitol. CFD revealed agglomerates impacting on the USP throat with higher localized velocity compared with the straight tube. CFD further showed a more complex flow pattern with high-velocity air jets in the AG, which explains the higher FPF for DSCG and the lower FPF for mannitol using the AG. The USP throat further de-agglomerated the emitted powder from the DPI when it did not sufficiently disperse the powder. Other tools such as laser diffract...Continue Reading

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Citations

Nov 16, 2013·Pharmaceutical Research·Irene ParisiniDarragh Murnane
Aug 27, 2013·Expert Review of Clinical Pharmacology·Mathieu Molimard, Peter D'Andrea
Mar 17, 2015·Drug Development and Industrial Pharmacy·Priscila RosaAndréa Inês Horn Adams
May 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viralkumar F PatelMarc B Brown
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Ana L SavianCristiane B da Silva
Jul 31, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter D AustinMarinos Elia
Nov 10, 2016·International Journal of Environmental Research and Public Health·Xiaohong OuYe Yang
Sep 18, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Reza TabeGoodarz Ahmadi
Aug 31, 2021·Advanced Drug Delivery Reviews·Michael Yee Tak ChowPhilip Chi Lip Kwok

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