Abstract
We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Aerosols emitting from a range of DPIs (Spinhaler®, Turbuhaler® and Osmohaler™) and induction ports (USP throat, straight tube, Alberta idealized mouth-throat geometry (AG)) were sized by laser diffraction. Total drug recovery was obtained by HPLC and fine particle fraction computed. Air flow patterns were simulated using Computational Fluid Dynamics (CFD). The straight tube did not de-agglomerate emitted powder. However, the USP throat and AG further de-agglomerated powders from the Spinhaler, but not the Turbuhaler and Osmohaler. While budesonide powder deposited similarly in all induction ports, deposition was significantly higher in the AG for both DSCG and mannitol. CFD revealed agglomerates impacting on the USP throat with higher localized velocity compared with the straight tube. CFD further showed a more complex flow pattern with high-velocity air jets in the AG, which explains the higher FPF for DSCG and the lower FPF for mannitol using the AG. The USP throat further de-agglomerated the emitted powder from the DPI when it did not sufficiently disperse the powder. Other tools such as laser diffract...Continue Reading
References
Feb 2, 1994·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A R Clark, A M Hollingworth
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·R Y YangA B Yu
Jun 8, 2001·Respiratory Medicine·P K BurnellG J Gibson
Mar 15, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hartwig SteckelBernd W Müller
Jun 27, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Z L WangW H Finlay
Oct 13, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Edgar A MatidaCarlos F Lange
Sep 27, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Yu ZhangWarren H Finlay
Sep 28, 2007·The European Respiratory Journal·W JanssensM Decramer
Jul 10, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Santoso AdiAibing Yu
Citations
Jul 31, 2013·International Journal of Pharmaceutics·Sani Ibn YakubuHenry Chrystyn
Nov 16, 2013·Pharmaceutical Research·Irene ParisiniDarragh Murnane
Aug 27, 2013·Expert Review of Clinical Pharmacology·Mathieu Molimard, Peter D'Andrea
Mar 17, 2015·Drug Development and Industrial Pharmacy·Priscila RosaAndréa Inês Horn Adams
Aug 2, 2013·Journal of Pharmaceutical Sciences·Qi Tony ZhouHak Kim Chan
Nov 18, 2015·Pharmaceutical Research·Francesca ButtiniViviana Sisti
May 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viralkumar F PatelMarc B Brown
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Ana L SavianCristiane B da Silva
Jul 24, 2015·The AAPS Journal·Sharon Shui Yee LeungHak-Kim Chan
Jul 31, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter D AustinMarinos Elia
Nov 10, 2016·International Journal of Environmental Research and Public Health·Xiaohong OuYe Yang
Jan 29, 2019·AAPS PharmSciTech·Stewart YeungPaul M Young
Sep 20, 2017·Future Medicinal Chemistry·Giuseppina IoeleGaetano Ragno
Sep 18, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Reza TabeGoodarz Ahmadi
May 28, 2019·AAPS PharmSciTech·Piyush MehtaAtmaram Pawar
Aug 23, 2020·AAPS PharmSciTech·William DoubAdrian P Goodey
Sep 25, 2020·Advanced Drug Delivery Reviews·Fen HuangRunyu Yang
Aug 31, 2021·Advanced Drug Delivery Reviews·Michael Yee Tak ChowPhilip Chi Lip Kwok
Sep 3, 2020·Acta Pharmaceutica Sinica. B·Xuejuan ZhangChuanbin Wu