Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis

International Journal of Oral and Maxillofacial Surgery
R K MenonM G Botelho

Abstract

The objectives of this systematic review were to investigate the efficacy of amoxicillin/amoxicillin-clavulanic acid for reducing the risk of postoperative infection after third molar surgery and to evaluate the adverse outcomes in these patients, as well as in healthy volunteers. A systematic search of four databases was performed on May 26, 2017. Eleven studies qualified for the qualitative analysis and eight were found suitable for meta-analysis. The results suggest that both amoxicillin-clavulanic acid and amoxicillin significantly reduce the risk of infection after third molar extraction (overall relative risk (RR) 0.25, P<0.001). However, with the exclusion of randomized controlled trials with a split-mouth design (due to an inadequate crossover period after antibiotic treatment), only amoxicillin-clavulanic acid was found to be effective (RR 0.21, P<0.001). The risk of adverse effects was significantly higher in the amoxicillin-clavulanic acid group (RR=4.12, P=0.023) than in the amoxicillin group (RR 1.57, P=0.405). In conclusion, amoxicillin-clavulanic acid and amoxicillin may significantly reduce the risk of infection after third molar extraction. However, their use in third molar surgery should be viewed with caution...Continue Reading

Citations

Mar 8, 2020·Equine Veterinary Journal·Rebekah KennedyPadraig M Dixon
Aug 30, 2019·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Juan Pablo Loyola-RodriguezOscar Sanchez-Adame
Oct 15, 2019·Journal of Investigative and Clinical Dentistry·Rohit K MenonMichael G Botelho
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Maria Del Mar Mariscal-CazallaMaria Victoria Olmedo-Gaya
Feb 25, 2021·The Cochrane Database of Systematic Reviews·Giovanni LodiMaddalena Manfredi
Jul 3, 2021·International Journal of Dentistry·Elaine Kueh Yue YiRohit Kunnath Menon
Oct 16, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Joe IwanagaSoichiro Ibaragi

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