Does thinner right entorhinal cortex underlie genetic liability to cannabis use?

Psychological Medicine
Subhadip Paul, Sagnik Bhattacharyya

Abstract

Although alterations in medial temporal lobe structures have been previously associated with use of cannabis, one of the most widely used illicit drugs, whether such alterations are a cause or effect of cannabis use has been unclear. In this cross-sectional observational study involving 404 twins/siblings, we have compared cortical thickness and surface area between groups of gender-matched sibling-pairs (concordant cannabis unexposed, concordant exposed and discordant for cannabis exposure) using permutation tests after controlling for potential confounds. Bi-variate polygenic model was used to assess the genetic and environmental contributions underlying cortical morphological phenotypes and frequency of cannabis use. Cortical thickness of the right entorhinal cortex was significantly lower in the concordant exposed siblings compared to both discordant unexposed and discordant exposed groups [false discovery rate (FDR)-corrected, q < 0.05]. The association between the right entorhinal cortex thickness and frequency of cannabis use is due to the contribution of significant shared additive genetic (ρg = -0.19 ± 0.08; p = 0.02) factors but not unique environment (ρe = 0.05 ± 0.09; p = 0.53). Significantly lower surface area of t...Continue Reading

References

Feb 15, 1977·Biochemical Pharmacology·R L Vigdahl, R H Tukey
May 1, 1987·Brain Research·R D Oades, G M Halliday
Jul 8, 1988·Science·P Rakic
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Aug 7, 2003·Journal of the International Neuropsychological Society : JINS·Igor GrantTanya Wolfson
Sep 30, 2005·The European Journal of Neuroscience·Mónica Muñoz, Ricardo Insausti
Jan 20, 2006·Cerebral Cortex·Christopher I WrightMichelle M Wedig
Mar 31, 2007·Experimental Brain Research·Yasuko Sugase-Miyamoto, Barry J Richmond
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Feb 1, 2008·Cerebral Cortex·Kiho ImSun I Kim
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·K Luan PhanHarriet de Wit
Jul 1, 2008·Biological Psychiatry·Stefan J BorgwardtPhilip K McGuire
Mar 21, 2009·Cerebral Cortex·Matthew S PanizzonWilliam S Kremen
Aug 21, 2009·Human Psychopharmacology·José Alexandre CrippaPaolo Fusar-Poli
Nov 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sagnik BhattacharyyaPhilip K McGuire
May 6, 2010·NeuroImage·Madhav ThambisettySusan M Resnick
Sep 30, 2010·Biological Psychiatry·Simone KühnJürgen Gallinat
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armin RaznahanJay N Giedd
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Jan 3, 2012·Biological Psychiatry·Christopher J HyattMichael C Stevens
Jan 18, 2012·NeuroImage·Bruce Fischl
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M ClarkBarry J Richmond
Jun 6, 2012·Molecular Psychiatry·C SchillingUNKNOWN IMAGEN consortium (www.imagen-europe.com)
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Madeline H MeierTerrie E Moffitt
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M ClarkBarry J Richmond
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
Jul 9, 2013·Current Pharmaceutical Design·A BatallaR Martín-Santos
Jul 9, 2013·Current Pharmaceutical Design·Matthijs G BossongPaul Allen
Aug 10, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Matthijs G BossongJ Martijn Jansma
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chi-Hua ChenWilliam S Kremen
Nov 5, 2013·Neuron·Daniel H Geschwind, Pasko Rakic
Nov 20, 2013·NeuroImage·Lara M WierengaSarah Durston
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols

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Citations

Nov 7, 2019·Molecular Psychiatry·Peter ManzaNora D Volkow
Jan 18, 2019·Journal of Neural Engineering·Subhadip PaulSagnik Bhattacharyya
Feb 2, 2019·European Archives of Psychiatry and Clinical Neuroscience·Valentina LorenzettiCarl A Roberts
Oct 3, 2020·Frontiers in Psychiatry·Grace Blest-HopleySagnik Bhattacharyya
Nov 7, 2020·Addiction Biology·Subhadip Paul, Sagnik Bhattacharyya
Aug 12, 2021·Cerebral Cortex·Jill A RabinowitzMiguel E Rentería

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