Does three-dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
A-F MinsartC Van Pachterbeke

Abstract

To compare three-dimensional (3D) power Doppler sonographic characteristics of fibroids with histopathological parameters. We evaluated sonographically 73 fibroids before myomectomy or hysterectomy. For each, the total fibroid volume, a shell of 3 mm and a 1-cm(3) spherical sample from the most vascularized area on subjective assessment were captured. 3D power Doppler vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were generated in the acquired volumes. The degree of cellularity, ischemic necrosis and fibrosclerosis, as well as CD31 and Ki-67 staining for vascular density and proliferation index, respectively, were estimated using the surgical sample. Pathological data were considered as dependent variables and ultrasound data as independent variables in multivariable logistic regression models including patients' characteristics. A high histological 'cellular activity score', combining hypercellularity, a fibrosclerosis rate < 25% and positive Ki-67 staining, was statistically related in multivariate analyses to high 3D power Doppler VI in spherical samples (odds ratio (OR), 1.1 (95% CI, 1.0-1.3), P < 0.05) and VFI (OR, 1.3 (95% CI, 1.0-1.8), P < 0.05). Positive CD31 staining was statistically...Continue Reading

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Citations

Aug 12, 2014·Journal of Clinical Ultrasound : JCU·Lotte L NieuwenhuisJudith A F Huirne
Feb 6, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Van den BoschD Timmerman
Sep 25, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P CzuczwarT Paszkowski
Dec 28, 2012·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shigeo OkudaSachio Kuribayashi
Feb 18, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·L L NieuwenhuisJaf Huirne
Aug 7, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L L NieuwenhuisJ A F Huirne

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