Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis

Journal of Endocrinological Investigation
Y FangL Tian

Abstract

To investigate the relationship between hypothyroidism, hyperthyroidism, thyroid hormone replacement, and the risk of breast cancer. We searched the PubMed, Cochrane Library, EMbase, Web of Science, and China Biology Medicine (CBM) databases through June 2016 to identify researches that assessed the relationship between thyroid dysfunction and the risk of breast cancer together with the impact of thyroid hormone substitution treatment on incidence of breast cancer. Quality of evidence was assessed per outcome, using GRADE. A total of 13 population-based studies including 24,808 participants were identified as eligible for this meta-analysis. A meta-analysis of 12 researches illustrated that hypothyroidism was not related to the risk for breast cancer [odds ratio (OR) = 0.83, 95% confidence interval (CI) 0.64-1.08, P = 0.162]. 10 researches illustrated that hyperthyroidism was also not related to the risk of breast cancer (OR = 1.03, 95% CI 0.83-1.30, P = 0.767). The impact of therapy was evaluated in six researches; there was no proof of a relationship between thyroid hormone substitution treatment and breast cancer with an overall OR of 0.83 (95% CI 0.57-1.21, P = 0.965). Our meta-analysis illustrated that thyroid dysfunction ...Continue Reading

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Citations

Apr 27, 2018·Thyroid : Official Journal of the American Thyroid Association·Anna M SawkaJacqueline Jonklaas
Mar 28, 2020·International Journal of Cancer. Journal International Du Cancer·Shuai YuanSusanna C Larsson
Nov 15, 2017·International Journal of Cancer. Journal International Du Cancer·Jasmine BrandtJonas Manjer
Mar 1, 2019·Frontiers in Endocrinology·Eilon KrashinOsnat Ashur-Fabian
Jan 11, 2020·Thyroid : Official Journal of the American Thyroid Association·Chien-Hsiang WengCharles B Eaton
May 20, 2020·Breast Cancer Research and Treatment·Laura BachMatthias Kalder
Sep 3, 2020·Archives of Endocrinology and Metabolism·Chandan Kumar JhaSaroj Kanta Mishra
Mar 30, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chun-Hao HuangMing-Hsin Yeh
May 26, 2021·Archives of Endocrinology and Metabolism·Chandan Kumar JhaSaroj Kanta Mishra
May 29, 2021·Future Science OA·Giuseppa GraceffaGianfranco Cocorullo

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