Does thyroidectomy, radioactive iodine therapy, or antithyroid drug treatment alter reactivity of patients' T cells to epitopes of thyrotropin receptor in autoimmune thyroid diseases?

The Journal of Clinical Endocrinology and Metabolism
M SolimanL J DeGroot

Abstract

The effect of treatment on thyroid antibody production and T cell reactivity to thyroid antigens was studied in 15 patients with Graves' disease (GD) before and after thyroidectomy, 19 patients with GD before and after radioactive iodine (RAI) therapy, and 9 patients maintained euthyroid on antithyroid drugs (ATD). Twenty subjects matched for age and sex without known thyroid disease served as controls. In GD patients, the responses of peripheral blood mononuclear cells (PBMC) and TSH receptor (TSHR)-specific T cell lines to recombinant human TSHR extracellular domain, thyroglobulin, and TSHR peptides were examined on the day of surgery or RAI therapy (day 0) and also 6-8 weeks and 3-6 months thereafter. Reactivity to TSHR peptides before surgery was heterogeneous and spanned the entire extracellular domain. Six to 8 weeks after subtotal thyroidectomy, the number of patients' PBMC responding to any peptide and the average number of recognized peptides decreased. A further decrease in the T cell reactivity to TSHR peptides was observed 3-6 months after surgery. The responses of PBMC from Graves' patients before RAI therapy were less than those in the presurgical group. Six to 8 weeks after RAI therapy, the number of patients res...Continue Reading

Citations

Apr 2, 2009·Journal of Endocrinological Investigation·L J De GrootJ V Hennessey
Jun 6, 2013·Clinical Endocrinology·Sarah Côté-BigrasDiane Rottembourg
Sep 8, 2016·Frontiers in Endocrinology·Hidefumi InabaTakashi Akamizu
Apr 14, 2005·Endocrine Reviews·Sandra M McLachlanBasil Rapoport
Dec 23, 1998·Endocrine Reviews·B RapoportS M McLachlan
Dec 30, 1999·International Reviews of Immunology·A MartinT F Davies

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