Does tight glycemic control improve outcomes in pediatric patients undergoing surgery and/or those with critical illness?

International Journal of General Medicine
Neil Christopher Forbes, Nicola Anders

Abstract

This literature review examines the current evidence regarding the potential usefulness of tight glycemic control in pediatric surgical patients. In adults, fluctuations in glucose levels and/or prolonged hyperglycemia have been shown to be associated with poor outcomes with respect to morbidity and mortality. This review begins by summarizing the findings of key papers in adult patients and continues by investigating whether or not similar results have been seen in pediatric patients by performing a comprehensive literature review using Medline (OVID). A database search using the OVID interface and including the search terms (exp glucose) AND (exp surgery) AND (exp Paediatric/pediatric) AND (exp Hypoglycaemia/hypoglycemia) AND (exp Hyperglycaemia/hyperglycemia) yielded a total of 150+ papers, of which 24 fulfilled our criteria. We isolated papers utilizing pediatric patients who were hospitalized due to illness and/or surgery. Our review highlights several difficulties encountered in addressing this potentially useful clinical intervention. An absence of scientifically robust and randomized trials and the existence of several small-powered trials yielding conflicting results mean we cannot recommend tight glycemic control in t...Continue Reading

Citations

Jul 14, 2014·The Veterinary Clinics of North America. Equine Practice·Jon Palmer
Nov 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mayumi L Prins

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Methods Mentioned

BETA
glycosylation

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