Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review

The Journal of Bone and Joint Surgery. American Volume
Mara L SchenkerSamir Mehta

Abstract

Existing guidelines recommend emergency surgical debridement of open fractures within six hours after injury. The aim of this study was to systematically review the association between time to operative debridement of open fractures and infection. Searches of the MEDLINE, EMBASE, and Cochrane computerized literature databases and manual searches of bibliographies were performed. Randomized controlled trials and cohort studies (retrospective and prospective) evaluating the association between time to operative debridement and infection after open fractures were included. Descriptive and quantitative data were extracted. A meta-analysis of patient cohorts who underwent early or delayed debridement was performed with use of a random effects model. The initial search identified 885 references. Of the 173 articles inspected further on the basis of the title, sixteen (six prospective and ten retrospective cohort studies with a total of 3539 open fractures) were included. No significant difference in the infection rate was detected between open fractures debrided early or late according to any of the time thresholds used in the included studies. Sensitivity analyses demonstrated no difference in infection rate between early and late d...Continue Reading

References

Nov 1, 1988·Archives of Surgery·E P DellingerP A Anderson
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
May 1, 1973·The Journal of Surgical Research·M C RobsonT J Krizek
Apr 1, 1995·Journal of Orthopaedic Trauma·K Kindsfater, E A Jonassen
Apr 8, 1999·Injury·C M Court-BrownM M McQueen
Oct 21, 2000·The Journal of Bone and Joint Surgery. British Volume·S GopalR M Smith
Feb 1, 2002·International Orthopaedics·I C IkemE A Bamgboye
Aug 13, 2002·Journal of Orthopaedic Trauma·Brian J HarleyDonald W Weber
May 29, 2003·Clinical Orthopaedics and Related Research·Edward C Yang, Jesse Eisler
Jun 11, 2003·Surgery·Atul A GawandeTroyen A Brennan
Jun 25, 2003·Journal of the American College of Cardiology·Jose P S HenriquesUNKNOWN Zwolle Myocardial Infarction Study Group
Sep 11, 2003·Clinical Orthopaedics and Related Research·Christopher B WhiteGeorge J Haidukewych
Nov 11, 2003·The Journal of Trauma·Monti KhatodWayne H Akeson
Mar 10, 2004·Annals of the Royal College of Surgeons of England·Jonathan SpencerDavid Woods
Jan 7, 2005·The Journal of Bone and Joint Surgery. American Volume·David L SkaggsJohn M Flynn
Feb 16, 2005·Injury·David A VolgasJorge E Alonso
Mar 11, 2005·Journal of Orthopaedic Trauma·Renan C CastilloUNKNOWN LEAP Study Group
Jun 29, 2006·Current Opinion in Infectious Diseases·Andrej Trampuz, Andreas F Widmer
Oct 14, 2006·BMC Medical Research Methodology·Leon BaxKarel G M Moons
Sep 7, 2007·ANZ Journal of Surgery·Jai SungaranMohamed Mourad
Sep 3, 2009·The Journal of Bone and Joint Surgery. American Volume·William M RicciRoss Leighton
Dec 3, 2009·Plastic and Reconstructive Surgery·Kevin C ChungGautam Kaul
Jan 6, 2010·The Journal of Bone and Joint Surgery. American Volume·Andrew N PollakUNKNOWN LEAP Study Group
Nov 5, 2010·Annals of the Royal College of Surgeons of England·W A TownleyD Camp
Feb 1, 2011·Journal of Orthopaedic Trauma·Surena NamdariSamir Mehta

❮ Previous
Next ❯

Citations

Nov 13, 2015·Orthopedics·Mohamad J Halawi, Michael P Morwood
May 16, 2013·Orthopedics·Julia Sanders, Cyril Mauffrey
Jan 8, 2015·Advances in Wound Care·Geoffrey D HanniganSamir Mehta
Sep 24, 2016·Journal of Orthopaedic Trauma·Nicholas J ErdleChristopher S Smith
Dec 17, 2016·Journal of Orthopaedic Trauma·Angela V ScharfenbergerLauren A Beaupre
Nov 20, 2015·The Journal of Bone and Joint Surgery. American Volume·Cheryl Reese LawingLaurence E Dahners
Oct 19, 2016·Journal of Orthopaedic Trauma·H Claude SagiUNKNOWN Center for Bone and Joint Infection
Jan 31, 2017·Acta orthopaedica et traumatologica turcica·Güzelali ÖzdemirErman Ceyhan
Mar 16, 2017·Infectious Disease Clinics of North America·Charalampos G Zalavras
May 11, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Anna N MillerPhilip Wolinsky
Nov 26, 2016·The Orthopedic Clinics of North America·Joshua C RozellSamir Mehta
Apr 17, 2014·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S P Ryan, V Pugliano
Nov 16, 2014·Foot & Ankle Specialist·Jeffrey Manway, Peter Highlander
Dec 12, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Melvin Chugh MakhniK Daniel Riew
Sep 25, 2017·Journal of Orthopaedic Trauma·Brendan R Southam, Michael T Archdeacon
Oct 21, 2017·Journal of Orthopaedic Trauma·Joey P JohnsonRoman A Hayda
Aug 9, 2017·Journal of Orthopaedic Trauma·Geoffrey S MarecekJackson Lee
Apr 25, 2018·JBJS Reviews·Erin A MillerStephen A Kennedy
Jun 12, 2018·Journal of Orthopaedic Trauma·Shaun F SteebyBrett D Crist
Aug 1, 2015·Revista Brasileira De Ortopedia·Pedro Nogueira GiglioJorge Dos Santos Silva
Jul 30, 2014·The Open Orthopaedics Journal·O'Brien C LJomha N M
Aug 25, 2018·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·William LackMadhav Karunakar
Jan 31, 2017·JBJS Reviews·Zachary R ZimmerSamir Mehta
Apr 19, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Justin SieblerMatthew Mormino
Jun 28, 2015·The Journal of the American Academy of Orthopaedic Surgeons·Col Romney C AndersenCol James R Ficke
Jun 27, 2020·Surgical Infections·Mursal GardeziDioscaris R Garcia
Dec 20, 2014·Journal of Orthopaedic Trauma·William D LackMichael J Bosse
May 8, 2020·Clinical Orthopaedics and Related Research·Patrick D AlbrightDavid W Shearer
May 28, 2015·Clinical Orthopaedics and Related Research·Kohei NishitaniJohn L Daiss
Mar 16, 2016·Journal of Orthopaedic Trauma·Apostolos D Prodromidis, Charalambos P Charalambous
Dec 19, 2016·Archives of Orthopaedic and Trauma Surgery·Thorsten JentzschGerrolt N Jukema
Nov 12, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D-Z HungY-P Lim
Feb 21, 2014·Journal of Orthopaedic Trauma·Mara L SchenkerKeith D Baldwin
Jun 10, 2015·Journal of Orthopaedic Trauma·William ObremskeyUNKNOWN Evidence-Based Quality Value and Safety CommitteeOrthopaedic Trauma Association, Writing Committee
Feb 28, 2020·JBJS Reviews·Nathanael HeckmannGeoffrey S Marecek
Apr 25, 2020·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Stuart CampbellNasim Ahmed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.