PMID: 9536929Apr 16, 1998Paper

Does total antioxidant status relate to outcome in very preterm infants?

Clinical Science
J A DruryR W Cooke

Abstract

1. In healthy humans, a balance exists between oxygen-derived free-radical production and their removal by antioxidants. In preterm infants inadequate antioxidant defences may contribute to the pathogenesis of some of the complications of prematurity. 2. Plasma total antioxidant status and malondialdehyde concentration were measured during the first 11 days of life in 25 infants to determine whether increased lipid peroxidation is associated with low extracellular antioxidant status. In a second group of infants, total antioxidant status was quantified within 12 h of birth, and subsequently on days 4 and 10 to investigate the hypothesis that adverse neonatal outcome is associated with low antioxidant status. 3. There may be a weak negative correlation between the total antioxidant status of infants and the lipid peroxidation marker malondialdehyde in plasma (r = -0.24, P = 0.056, n = 89) during the first 11 days of life. In the second group of infants, total antioxidant status was found to be significantly related to plasma urate and bilirubin levels, but not to adverse neonatal outcomes such as chronic lung disease, intraventricular haemorrhage, retinopathy of prematurity or death. 4. If adverse neonatal outcomes are due to in...Continue Reading

Citations

Apr 15, 2016·Paediatrics and International Child Health·Eman Abdel Ghany Abdel GhanyJihan Seid Hussein
Apr 5, 2013·The Journal of Obstetrics and Gynaecology Research·Hüseyin AltunhanRahmi Örs
Feb 16, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T GaálL Sümeghy
May 6, 2015·Paediatrics and International Child Health·Eman Abdel Ghany Abdel GhanyJihan Seid Hussein
Sep 15, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Barry WeinbergerThomas Hegyi
Sep 15, 2007·Journal of Paediatrics and Child Health·Esad KokluRecep Saraymen
May 7, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Joshua D MilnerAyman El-Mohandes
Jun 3, 2004·Pediatrics·Thomas W Sedlak, Solomon H Snyder

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