Does tranexamic acid reduce blood loss and transfusion rates in unicompartmental knee arthroplasty?

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Boonchana Pongcharoen, Chaivet Ruetiwarangkoon

Abstract

Tranexamic acid (TXA) has proven its efficacy in reducing blood loss and the need for blood transfusions in patients who have undergone a total knee arthroplasty (TKA) surgical procedure. However, no study has investigated the benefits of TXA in unicompartmental knee arthroplasty (UKA), especially, in regard to minimally invasive surgery (MIS) UKA. The purpose of this study is to attempt to prove the benefits of TXA and to identify the risks for blood loss and need for blood transfusions in MIS UKA. We prospectively followed 99 patients (120 knees) who had been treated with cemented MIS UKAs from January, 2011 to April, 2013 and who had had a minimum of 12 months of follow-up. The patients were divided into two groups; the TXA group (54 patients; 60 knees) and a control group (55 patients; 60 knees). The amount of blood loss collected in the drains was assessed 24-h postoperatively. The rates of peri-operative blood transfusions and hematocrit levels were recorded. We have also determined the factors affecting the peri-operative blood loss and these include gender, age, and body mass index (BMI). The patients in TXA group tend to have lower blood loss than had been seen in the control group, but the differences were not signifi...Continue Reading

References

Dec 16, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kenneth E DeHaven
Apr 7, 2004·The Journal of Arthroplasty·Matthew R BongPaul E Di Cesare
Mar 29, 2006·International Orthopaedics·Narayana PrasadArun Mullaji
Feb 2, 2013·International Orthopaedics·Takao IwaiMasayuki Hamada
Jul 27, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Pierre-Emmanuel SchwabEmmanuel Thienpont
Aug 28, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Liu ZhaohuiZhu Guangduo
Apr 19, 2015·Journal of Orthopaedic Surgery and Research·Malin S CarlingHelena Brisby

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