Does transient elastography (FibroScan®) have a role in decision making in hepatocellular carcinoma?

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Antonio PesceStefano Puleo

Abstract

Portal hypertension has been reported as a negative prognostic factor and a relative contraindication for liver resection. This study considers a possible role of fibrosis evaluation by transient elastography (FibroScan(®)) and its correlation with portal hypertension in patients with cirrhosis, and discusses the use of this technique in planning therapeutic options in patients with hepatocellular carcinoma (HCC). A total of 77 patients with cirrhosis, 42 (54.5%) of whom had HCC, were enrolled in this study during 2009-2011. The group included 46 (59.7%) men. The mean age of the sample was 65.2 years. The principle aetiology of disease was hepatitis C virus (HCV)-related cirrhosis (66.2%). Liver function was assessed according to Child-Pugh classification. In all patients liver stiffness (LS) was measured using FibroScan(®). The presence of portal hypertension was indirectly defined as: (i) oesophageal varices detectable on endoscopy; (ii) splenomegaly (increased diameter of the spleen to ≥ 12 cm), or (iii) a platelet count of <100,000 platelets/mm(3). Median LS in all patients was 27.9 kPa. Portal hypertension was recorded as present in 37 patients (48.1%) and absent in 40 patients (51.9%). Median LS values in HCC patients wit...Continue Reading

References

Jul 1, 1993·Seminars in Surgical Oncology·M MakuuchiS Kawasaki
Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Nov 12, 2003·Archives of Surgery·Hiroshi ImamuraMasatoshi Makuuchi
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ronnie Tung-Ping Poon, Sheung-Tat Fan
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Jun 1, 2006·World Journal of Surgery·Lorenzo CapussottiHedayat Bouzari
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco VizzuttiMassimo Pinzani
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jacques Belghiti, Reza Kianmanesh
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
Dec 17, 2008·Gastroentérologie Clinique Et Biologique·V de Lédinghen, J Vergniol
Jul 2, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jean-Nicolas VautheyUNKNOWN Society for Surgery of the Alimentary Tract
Sep 21, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Krit KitisinAllan Tsung

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Citations

Feb 11, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Atsushi NanashimaTakeshi Nagayasu
Jul 18, 2018·European Journal of Gastroenterology & Hepatology·Antonio PesceStefano Puleo
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonio PesceKatia Mangano

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