PMID: 7049293May 1, 1982Paper

Does tryptophan potentiate clomipramine in the treatment of agoraphobic and social phobic patients?

The British Journal of Psychiatry : the Journal of Mental Science
J C PecknoldL Wrzesinski

Abstract

A 10 week double blind study of 24 agoraphobics and 16 social phobics all on clomipramine compared the effect of adding tryptophan or placebo. Tryptophan did not potentiate the beneficial effect of clomipramine on phobic avoidance, phobic fears or the incidence of panic attacks. Neither was the presence of depression a factor of outcome.

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