Does undetectable basal Tg measured with a highly sensitive assay in the absence of antibodies and combined with normal ultrasonography ensure the absence of disease in patients treated for thyroid carcinoma?

Arquivos brasileiros de endocrinologia e metabologia
Pedro Weslley S Rosário, Augusto Flávio Campos Mineiro Filho

Abstract

It has been proposed that, in patients treated for well-differentiated thyroid carcinoma, undetectable basal thyroglobulin (Tg) levels measured with a highly sensitive assay in the absence of anti-thyroglobulin antibodies (TgAb) and combined with negative neck ultrasonography (US) ensured the absence of disease. We report a series of five patients with well-differentiated (papillary) carcinoma submitted to total thyroidectomy with apparently complete tumor resection, followed by remnant ablation with (131)I (100-150 mCi), who had no distant metastases upon initial post-therapy whole-body scanning. When tumor recurrence or persistence was detected, these patients presented undetectable basal Tg (0.1 ng/mL) in the absence of TgAb, and US showed no anomalies. Two patients had lymph node metastases, one had mediastinal metastases, bone involvement was observed in one patient, and local recurrence in one. We conclude that further studies are needed to define in which patients undetectable basal Tg (negative TgAb) combined with negative US is sufficient, and no additional tests are required.

References

Jul 11, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaGiuseppe Spriano
Nov 28, 2009·Arquivos brasileiros de endocrinologia e metabologia·Fabián PitoiaHugo Niepomniszcze
Mar 11, 2011·The Journal of Clinical Endocrinology and Metabolism·M BrassardUNKNOWN THYRDIAG Working Group

❮ Previous
Next ❯

Citations

Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley RosárioUNKNOWN Sociedade Brasileira de Endocrinologia e Metabologia
Mar 3, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Samantha EpsteinJason N Itri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.