Does urinary cytology have a role in haematuria investigations?

BJU International
Wei Shen TanDETECT I trial collaborators

Abstract

To determine the diagnostic accuracy of urinary cytology to diagnose bladder cancer and upper tract urothelial cancer (UTUC) as well as the outcome of patients with a positive urine cytology and normal haematuria investigations in patients in a multicentre prospective observational study of patients investigated for haematuria. The DETECT I study (clinicaltrials.gov NCT02676180) recruited patients presenting with haematuria following referral to secondary case at 40 hospitals. All patients had a cystoscopy and upper tract imaging (renal bladder ultrasound [RBUS] and/ or CT urogram [CTU]). Patients, where urine cytology were performed, were sub-analysed. The reference standard for the diagnosis of bladder cancer and UTUC was histological confirmation of cancer. A positive urine cytology was defined as a urine cytology suspicious for neoplastic cells or atypical cells. Of the 3 556 patients recruited, urine cytology was performed in 567 (15.9%) patients from nine hospitals. Median time between positive urine cytology and endoscopic tumour resection was 27 (IQR: 21.3-33.8) days. Bladder cancer was diagnosed in 39 (6.9%) patients and UTUC in 8 (1.4%) patients. The accuracy of urinary cytology for the diagnosis of bladder cancer and...Continue Reading

Associated Clinical Trials

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Citations

Dec 7, 2018·Journal of Internal Medicine·W S TanUNKNOWN DETECT I trial collaborators
Nov 18, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sruthi BabuKenneth R Shroyer
Dec 31, 2020·Scandinavian Journal of Urology·Tammer HemdanPer-Uno Malmström
Mar 20, 2021·La Revue de médecine interne·Edouard FlamarionMarie Aude Penet

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Methods Mentioned

BETA
biopsy
urine collection

Clinical Trials Mentioned

NCT02676180

Software Mentioned

SPSS

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