Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review

The American Journal of Geriatric Pharmacotherapy
Kairav ShahMark E Kunik

Abstract

Hypertension appears to contribute to the development of dementia. Antihypertensive drugs may play an important role in altering the incidence or progression of dementia, particularly dementia of the vascular type; however, the neuroprotective effects of these agents in other types of dementia are not well characterized. The main aims of this review were to examine the relationship between use of antihypertensive agents and the incidence and progression of Alzheimer's dementia (AD), vascular dementia (VaD), and unspecified dementia, and to consider whether these agents may be neuroprotective. A search of the English-language literature (January 1996-August 2009) was conducted using PubMed, Ovid MEDLINE, EBSCO MEDLINE, and the Cochrane Database of Systematic Reviews for publications mentioning both antihypertensive drugs and dementia. A combination of searches was performed using the following terms: antihypertensive drugs, dementia, cognitive impairment, Alzheimer's dementia, vascular dementia, progression of cognitive impairment, severity of cognitive impairment, severity of dementia, prevalence, and incidence. Searches were also performed using the names of antihypertensive drug classes. The bibliographies of all retrieved ar...Continue Reading

References

Apr 27, 1996·Lancet·I SkoogA Svanborg
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Leonardo PantoniDomenico Inzitari
Mar 3, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ihab HajjarPaul Eleazer
Jun 28, 2005·Current Alzheimer Research·Egemen Savaskan
Aug 6, 2008·Dementia and Geriatric Cognitive Disorders·Esther L G E KoedamWiesje M van der Flier

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Citations

Apr 27, 2012·Pflügers Archiv : European journal of physiology·John W Wright, Joseph W Harding
Jul 16, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Avron Spiro, Christopher B Brady
Dec 18, 2012·Cardiovascular Psychiatry and Neurology·Jack C de la Torre
May 1, 2011·Therapeutic Advances in Chronic Disease·Danielle WilsonCraig W Ritchie
Jul 3, 2010·EMBO Molecular Medicine·Ariela BenigniGiuseppe Remuzzi
Nov 8, 2013·Journal of Human Hypertension·L C BeishonS P Conroy
Aug 26, 2014·Journal of the American Society of Hypertension : JASH·Michael L AloscoLawrence H Sweet
Oct 21, 2010·European Archives of Psychiatry and Clinical Neuroscience·Frank JessenWolfgang Maier
Jan 16, 2013·International Journal of Hypertension·Marie-Odile Guimond, Nicole Gallo-Payet
Jan 16, 2014·International Review of Psychiatry·Joann T TschanzConstantine G Lyketsos
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Wendy Wei Qiao QiuDavid C Steffens
Jul 22, 2011·Lancet Neurology·Deborah E Barnes, Kristine Yaffe
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding
Sep 8, 2010·Trends in Molecular Medicine·Valérie LeducJudes Poirier
Dec 17, 2015·Journal of the Neurological Sciences·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Sep 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maximilian WiesmannJurgen A H R Claassen
Jun 6, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Matthew BaumgartHarry Johns
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K J AnsteyJ Young
Sep 16, 2010·The International Journal of Pharmacy Practice·Paul R Gard
Apr 24, 2014·Journal of the American Medical Directors Association·Veronika van der WardtJohn Gladman
Oct 27, 2015·TheScientificWorldJournal·Guang-Xia ShiCun-Zhi Liu
Oct 23, 2012·Neurobiology of Aging·Leif ØstergaardMark J West
Jul 17, 2012·Experimental Gerontology·Andrius Baskys, Jin-xiang Cheng
Dec 31, 2011·Neurobiology of Aging·Natalya V PonomarevaEvgeny I Rogaev
Dec 22, 2011·Ageing Research Reviews·Cecilia OseraGiovanni Ricevuti
May 12, 2012·Journal of the Neurological Sciences·Amos D KorczynLea T Grinberg
Dec 3, 2014·Brain Research Bulletin·Xiu-Zhen ZhangGuang-Yan Tang
Aug 1, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Shan ZhuangCheng-Ming Xing
Apr 16, 2014·Alzheimer Disease and Associated Disorders·Simona LattanziMauro Silvestrini
Dec 26, 2015·American Journal of Alzheimer's Disease and Other Dementias·Abhishek S ChitnisMichael L Johnson
Aug 10, 2016·Journal of Geriatric Psychiatry and Neurology·Ayesha KhanClive Ballard
Feb 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leif ØstergaardGrethe Andersen
May 17, 2017·Journal of Hypertension·Tessa van MiddelaarWillem A van Gool
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Susan JongstraEdo Richard
Jan 26, 2011·Nature Reviews. Endocrinology·Mark W J StrachanJacqueline F Price
Aug 29, 2012·Hypertension·Sara ContiAriela Benigni
Jan 11, 2014·Journal of Hypertension·Wei-Che ChiuUNKNOWN Health Data Analysis in Taiwan (hDATa) Research Group

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