Does Vacuum-assisted Closure Reduce the Risk of Wound Complications in Patients With Lower Extremity Sarcomas Treated With Preoperative Radiation?

Clinical Orthopaedics and Related Research
Meena BediJohn C Neilson

Abstract

Although preoperative radiation followed by wide local excision yields excellent local control in soft tissue sarcomas, the risk of wound complications is reported to be higher compared with the incidence in patients who were administered postoperative radiation therapy. Vacuum (vac)-assisted closure may improve wound healing, but it is unknown whether vac-assisted closure during soft tissue sarcoma resection may reduce the risk of wound complications or impair local disease control. (1) Does the use of a wound vac application at the time of soft tissue sarcoma resection reduce the risk of developing wound complications after lower extremity sarcoma resection? (2) Is vac-assisted closure associated with an increased risk of local relapse? From 2000 to 2016, 312 patients with stage I to III soft tissue sarcomas were treated. Of these, 123 were treated with preoperative radiation ± chemotherapy followed by limb-sparing resection based on tumor location, size, grade, histology, and patient age. There was a minimum followup of 12 months. Radiation was delivered generally based on tumor size, grade, superficial versus deep nature, and proximity to neurovascular structures. Chemotherapy was administered in patients < 70 years old wit...Continue Reading

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Citations

Mar 27, 2019·The Cochrane Database of Systematic Reviews·Joan WebsterWendy P Chaboyer
Feb 7, 2020·Current Treatment Options in Oncology·Elyse J BrinkmannMatthew T Houdek
Sep 19, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin K WilkeAntonio J Forte
Jun 30, 2021·International Wound Journal·Yen-Jen WangChang-Cheng Chang
Jul 8, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Benjamin K WilkeAntonio J Forte
Aug 20, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Benjamin K WilkeAntonio J Forte

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