Does Visceral or Subcutaneous Fat Influence Peripheral Cortical Bone Strength During Adolescence? A Longitudinal Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Natalie A GlassSteven M Levy

Abstract

This study evaluated the longitudinal relationships among visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and peripheral bone strength during adolescence. Fat and lean mass, VAT and SAT area, and android/gynoid (A/G) ratio were estimated with DXA. Our main outcome was strength-strain index (SSI), an indicator of peripheral bone strength estimated by pQCT at the radius and tibia. Sex-specific analyses evaluated the longitudinal bone-fat relationship from ages 11 to 19 years with linear mixed models using biological age as the time variable and adjusted for limb length and lean mass in 182 girls and 167 boys. Variables were standardized (mean = 0, SD = 1) prior to model fitting and results shown are parameter estimates ± SE. Fat mass and SAT were positively associated with SSI (radius: 0.07 ± 0.02, p = 0.003 and 0.05 ± 0.02, 0.041, respectively; tibia: 0.09 ± 0.02, p < 0.001 and 0.08 ± 0.02, p < 0.001, respectively) prior to, but not following adjustment for lean mass in girls. In contrast, fat mass and SAT were negatively associated with radial SSI, both before and after adjustment for lean mass in boys (fat mass: -0.05 ± 0.01, p = 0.001; SAT: -0.04 ± 0.01, p = 0.004). In full models, negative associations were...Continue Reading

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Citations

Oct 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Joseph M KindlerConnie M Weaver
Aug 12, 2020·Diabetes Care·Joseph M KindlerBabette S Zemel
Jun 3, 2018·Hormones : International Journal of Endocrinology and Metabolism·Christos SavvidisAnastasia D Dede
May 16, 2019·Journal of Obesity & Metabolic Syndrome·Paul Dimitri
Mar 19, 2020·International Journal of Environmental Research and Public Health·Jingjing LiangYanyan Song
Jan 8, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z ZhangX-H Zhou
Jun 26, 2021·Pediatric Obesity·Valérie JulianDavid Thivel
Jul 8, 2021·Journal of Pediatric Orthopedics·Jennifer J BeckBarbara Minkowitz

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