Does vitamin D deficiency affect placental inflammation or infections among very low birth weight infants?

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Subhash PuthurayaRonald Thomas

Abstract

Examine the association between placental inflammation and neonatal infections, and 25OH vitamin D (25OH D) levels at birth among very low birth weight infants (VLBWI). Serum 25OH D levels were measured in 89 VLBWI (≤1250 g) and 47 mothers on day one, and in 78 infants on day 21. Placentas were examined for maternal and fetal inflammation. Infants were divided into deficient (≤10 ng/ml) and adequate (>10 ng/ml) groups based on 25OH D levels on day 1. Mean ± SD maternal levels of 25OH D (21 ± 9 ng/ml) correlated with infants' levels (15 ± 8 ng/ml), (p < .001). 25OH D levels were lower in deficient (32/89) than in adequate group (8 ± 2 versus 20 ± 7 ng/ml, p = .011). Infants' 25OH D levels rose significantly by day 21 (p < .001). Univariate analyses showed no differences between infant groups in maternal or fetal inflammation, or neonatal infections (p > .05). Logistic regression analyses revealed no association between deficient 25OH D levels and the odds of maternal or fetal inflammation or other infections. Levels of 25OH D did not correlate with severity of placental inflammation. Deficient levels of 25OH D at birth are not associated with the occurrence of placental inflammation or neonatal infections among VLBWI.

References

Jan 30, 2004·American Journal of Obstetrics and Gynecology·Monica M Lahra, Heather E Jeffery
Jul 28, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Evelyne van Etten, Chantal Mathieu
Mar 9, 2007·The American Journal of Clinical Nutrition·Carlos A CamargoMatthew W Gillman
May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa M BodnarJames M Roberts
Jan 28, 2009·Nature Reviews. Immunology·J Rodrigo MoraUlrich H von Andrian
Apr 1, 2009·The British Journal of Nutrition·Valerie A HolmesJulie M W Wallace
Feb 2, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Diane L Kamen, Vin Tangpricha
Aug 10, 2010·American Journal of Obstetrics and Gynecology·Christopher J RobinsonDonna D Johnson
Sep 25, 2010·Placenta·J S ShinD M Nelson
Apr 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Valencia P WalkerRobert L Modlin
Jun 16, 2011·Endocrinology·Sylvia Christakos, Hector F DeLuca
Dec 14, 2011·Archives of Biochemistry and Biophysics·N Q Liu, M Hewison
Jan 20, 2012·Dermato-endocrinology·Dima A YoussefAlan N Peiris
Mar 15, 2012·European Journal of Clinical Nutrition·E K NicholsM K Serdula
Jun 26, 2012·European Journal of Internal Medicine·Y H M PoelS Simsek
Jul 28, 2012·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Jeanine SentiCindy Miller Anderson
Nov 8, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·N ClancyE J Molloy
May 17, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michelle ScienceMark Loeb
Jun 8, 2013·Obstetrics and Gynecology·Lisa M BodnarUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU)
Jul 16, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Nagendra MonangiHenry T Akinbi
Aug 16, 2013·The American Journal of Clinical Nutrition·Sadeq A QuraishiKenneth B Christopher
Aug 29, 2013·Critical Care Medicine·Takuhiro MoromizatoKenneth B Christopher
Oct 8, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sema ArayiciUgur Dilmen
Oct 15, 2013·Pediatric Research·Heather H BurrisHelen Christou
Aug 8, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·M CetinkayaG Aydemir
Feb 11, 2015·The Journal of Endocrinology·J A TamblynM D Kilby
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lorenza PugniFabio Mosca
Dec 23, 2015·Korean journal of pediatrics·Sook-Hyun ParkHeng-Mi Kim
May 26, 2016·Archives of Pathology & Laboratory Medicine·T Yee KhongSanne J Gordijn

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Citations

May 21, 2020·Nutrients·Bianca Schröder-HeurichFrauke von Versen-Höynck
Jan 22, 2021·Food Science & Nutrition·Zebenay Workneh BitewAyinalem Alemu

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