PMID: 18705546Aug 19, 2008Paper

Does zero balance ultrafiltration decrease the incidence of post-cardiopulmonary bypass atrial fibrillation?

The Journal of Extra-corporeal Technology
Mark T LucasDavid W Holt

Abstract

Atrial fibrillation is the most frequent cardiac dysrhythmia after cardiac surgery. Postoperative atrial fibrillation (Afib) is shown to increase risk of stroke, congestive heart failure, and hemodynamic instability leading to increased hospital length of stay and cost. Inflammation and degenerative histologic changes in cell structure because of age may predispose patients to a higher susceptibility. Cardiac surgery with cardiopulmonary bypass (CPB) induces a systemic inflammatory response syndrome (SIRS) responsible for a number of postoperative complications including arrhythmias. Zero balance ultrafiltration (ZBUF) has been shown to decrease SIRS by removing some of its mediators and products from the blood. The purpose of this retrospective analysis is to determine whether ZBUF does decrease the incidence of Afib after CPB. Retrospective review was conducted on consecutive primary coronary artery bypass patients placed on CPB from the period of January 2004 to June 2006. Data were collected from perfusion records, patient charts, blood bank records, and a cardiac surgery clinical database consisting of patient demographics, occurrence of postoperative Afib, ZBUF, blood product administration, antifibrinolytic use, bypass a...Continue Reading

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