PMID: 6412684Aug 1, 1983Paper

Dog and human acid beta-D-galactosidases are structurally similar

The Biochemical Journal
J J Hubert, J S O'Brien

Abstract

The purification of dog liver acid beta-galactosidase is described. The dog enzyme migrated as a single major band on polyacrylamide-gel electrophoresis in the presence of sodium dodecyl sulphate, with a molecular weight of 60000. Antiserum raised against purified human liver acid beta-galactosidase cross-reacted with beta-galactosidase from dog liver, but not with those from cat liver or Escherichia coli. Tryptic peptide maps of the dog and human acid beta-galactosidases indicate that 21 of the 24 peptides observed were homologous; a similar result was obtained after chymotryptic peptide mapping. We conclude that dog and human acid beta-galactosidases are structurally similar, and that canine GM1 gangliosidosis (acid beta-galactosidase deficiency) is an excellent model for the same disease in man.

Citations

May 17, 1996·American Journal of Medical Genetics·A J Ahern-RindellJ S O'Brien
Jun 28, 2007·Nursing Science Quarterly·Anthony J Welch
Jul 11, 2000·The Veterinary Record·O YamatoY Maede
Oct 16, 1999·Science·S J O'BrienJ A Marshall Graves
Oct 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S HotamisligilS Raghavan

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