Dog as a mammalian genetic model

Médecine sciences : M/S
Francis GalibertChristophe Hitte

Abstract

Up to recently, studies on dog genetics were rather scare notwithstanding the enormous potential that the canine model can offer in the study of the genotype/phenotype relationship and the analysis of the causes of many genetic diseases, with simple or complex inheritance, that affect dogs but also the human population. This potentiality is essentially due to the natural history of dogs whose domestication from wolves dated back 15,000 years, at least. All modern dogs originated from a limited number of female wolves from Eastern Asia. By applying a combination of selections and strong inbreeding practices, humans have created over 350 breeds, each of them corresponding to a genetic isolate and altogether offering a unique panel of polymorphism never encountered in any other mammals. In this review we summarized what makes dogs an unavoidable model. Contrary to the classical models like the two yeasts, nematode, fish, fly, mouse, or rat mainly used to understand the function of genes, dog with the creation across the centuries of numerous breeds offers a unique opportunity to study the role of their alleles. We report recent data on the construction of genomic maps and on the sequencing program of the dog genome launched by the...Continue Reading

References

May 1, 1994·Nature Genetics·M A WalterP N Goodfellow
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M L SuberR L Hurwitz
Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F LingaasG Dolf
Jun 13, 1997·Science·C VilàR K Wayne
Jan 27, 1998·Genomics·C S MellershE A Ostrander
Jul 10, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Z JiangF Galibert
Jan 8, 1999·Genomics·C PriatF Galibert
Aug 3, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C PriatF Galibert
Aug 12, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F VignauxF Galibert
Feb 5, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C S MellershF Galibert
Feb 26, 2000·Trends in Genetics : TIG·E A OstranderD F Patterson
Sep 14, 2000·Genome Research·E A Ostrander, L Kruglyak
Apr 28, 2001·Nature Genetics·G M AclandJ Bennett
Jan 26, 2002·Human Molecular Genetics·Bart van De SluisCisca Wijmenga
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·James W KijasGregory M Acland
May 16, 2002·The Journal of Heredity·B ZangerlG D Aguirre
Jul 26, 2002·Human Molecular Genetics·Duska J SidjaninElaine A Ostrander
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Katherine Parker PonderMark E Haskins
Nov 26, 2002·Science·Peter SavolainenThomas Leitner
Nov 26, 2002·Science·Jennifer A LeonardCarles Vilà
Nov 26, 2002·Science·Brian HareMichael Tomasello
Apr 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard GuyonElaine A Ostrander
Sep 27, 2003·Science·Ewen F KirknessJ Craig Venter
May 25, 2004·Science·Heidi G ParkerLeonid Kruglyak
Jun 12, 2004·Science·Juliane KaminskiJulia Fischer

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Citations

Mar 5, 2008·BMC Veterinary Research·Thierry VilbouxCatherine André
May 16, 2007·Médecine sciences : M/S·Simone Gilgenkrantz
Oct 10, 2006·Médecine sciences : M/S·Francis Galibert, Catherine André
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Jul 14, 2005·Nature Reviews. Genetics·Christophe HitteFrancis Galibert
Jan 15, 2009·Molecular Ecology·B GauffreJ F Cosson
Dec 16, 2016·Molecular Ecology Resources·Aurélie KhimounStéphane Garnier
Aug 16, 2016·Ecology and Evolution·Carlos Henrique Dos A Dos SantosVera Maria F Almeida-Val
Feb 5, 2016·Ecology and Evolution·Juan CarranzaJavier Pérez-González

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