Dog models of naturally occurring cancer

Trends in Molecular Medicine
Jennie L RowellCarlos E Alvarez

Abstract

Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies disease mapping and pharmacogenomics. Dogs age five- to eight-fold faster than do humans, share environments with their owners, are usually kept until old age and receive a high level of health care. Farseeing investigators recognized this potential and, over the past decade, have developed the necessary tools and infrastructure to utilize this powerful model of human disease, including the sequencing of the dog genome in 2005. Here, we review the nascent convergence of genetic and translational canine models of spontaneous disease, focusing on cancer.

References

Sep 30, 1994·Science·E S Lander, N J Schork
Mar 1, 1996·Neurobiology of Aging·B J CummingsC W Cotman
Jan 1, 1997·DNA Sequence : the Journal of DNA Sequencing and Mapping·L NasirS W Reid
Aug 6, 1998·The Veterinary Journal·G RuL T Glickman
Jan 22, 2000·Veterinary Pathology·R A Levine, M A Fleischli
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Hansen, C Khanna
Jun 8, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·David R Sargan
Oct 28, 2005·The Journal of Heredity·D R SarganJ M Dobson
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Jun 1, 2006·Animal Genetics·A T LiaoC A London
Sep 12, 2006·Nature Biotechnology·Chand KhannaStephen Withrow
Feb 13, 2007·International Journal of Cancer. Journal International Du Cancer·Natacha Entz-WerleAnnie Babin
May 29, 2007·Leukemia Research·William C KisseberthThomas J Rosol
Jan 19, 2008·Nature Reviews. Cancer·Melissa Paoloni, Chand Khanna
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Matthew Breen, Jaime F Modiano
Mar 4, 2008·Journal of the American Veterinary Medical Association·Allison J Shepherd
Aug 21, 2008·Nature Reviews. Genetics·Elinor K Karlsson, Kerstin Lindblad-Toh
Nov 7, 2008·Veterinary Surgery : VS·Jolle KirpensteijnGerard R Rutteman
Feb 4, 2009·Virchows Archiv : an International Journal of Pathology·Fredrik MertensNils Mandahl
Mar 17, 2009·Annals of Neurology·Toshifumi YokotaEric Hoffman
Mar 19, 2009·ILAR Journal·Zejing WangRainer Storb
Apr 2, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Rachael ThomasMatthew Breen
Jan 1, 2008·APMIS. Supplementum·Hans GamlemEystein Glattre
Jun 13, 2009·Behavioural Processes·Angel M ElgierMariana Bentosela
Jun 16, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M CohenJon C Cook
Jun 30, 2009·BMB Reports·Yoichi GondoShigeru Makino
Aug 1, 2009·BMC Veterinary Research·Jesús Aguirre-HernándezDavid R Sargan
Aug 29, 2009·Science·Virginia Morell
Sep 8, 2009·Topics in Companion Animal Medicine·Matthew Breen
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chand KhannaSteven Hirschfeld
Nov 26, 2009·Journal of Comparative Pathology·B N Bonnett, A Egenvall
Jan 16, 2010·Disease Models & Mechanisms·Abigail L Shearin, Elaine A Ostrander
Jan 21, 2010·Genome Research·Jie TangShaying Zhao
Feb 6, 2010·Expert Review of Anticancer Therapy·Dimitrios Krikelis, Ian Judson
Mar 11, 2010·Virchows Archiv : an International Journal of Pathology·Louis Guillou, Alain Aurias
Jan 1, 2009·Journal of Cancer Epidemiology·J Armando VillamilCharles W Caldwell
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lee A HonigbergJoseph J Buggy
Aug 17, 2010·PLoS Biology·Adam R BoykoElaine A Ostrander
Aug 26, 2010·Expert Review of Anticancer Therapy·Joseph ChaoGeorge Somlo

❮ Previous
Next ❯

Citations

Dec 6, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carlos E Alvarez, Joshua M Akey
Jul 9, 2013·Trends in Molecular Medicine·Marco DuranteKathryn D Held
Feb 4, 2012·Genome Research·Emily A VucicWan L Lam
Jul 3, 2013·Journal of Translational Medicine·Noel R MonksCraig P Webb
Mar 22, 2013·Acta Veterinaria Scandinavica·Tonje Seim-WikseEllen Skancke
Oct 12, 2013·PloS One·Kinga MajchrzakMagdalena Król
Jun 11, 2014·PloS One·Saskia WillenbrockHugo Murua Escobar
Jun 28, 2014·BMC Research Notes·Teresia BuzaDaniel G Peterson
May 22, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Michael A HarkeyAlexander Travis
Feb 23, 2013·Biochimica Et Biophysica Acta·Romina TripaldiSaverio Alberti
Jun 18, 2014·ILAR Journal·Brian W Davis, Elaine A Ostrander
Jun 18, 2014·ILAR Journal·Amy K LeBlanc
Jun 18, 2014·ILAR Journal·Joelle M FengerWilliam C Kisseberth
May 21, 2014·Viruses·Ivaylo GentschevAladar A Szalay
Aug 7, 2014·Journal of Natural Science, Biology, and Medicine·Soumyaranjan PatiShantibhusan Senapati
Dec 17, 2014·TheScientificWorldJournal·Gerardo Claudio Glikin, Liliana María Elena Finocchiaro
Nov 14, 2015·Annual Review of Animal Biosciences·Heather L GardnerCheryl A London
Dec 26, 2015·Viruses·Diana SánchezRosa Elena Sarmiento-Silva
Nov 8, 2013·Expert Review of Vaccines·Pier-Luigi LolliniPatrizia Nanni
Apr 29, 2014·Journal of Proteomics·Ingrid MillerElisabetta Gianazza
Feb 22, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Salomé S PinhoFátima Gärtner
Jan 17, 2012·Veterinary Immunology and Immunopathology·J WassermanT L Papenfuss
Dec 20, 2011·Veterinary Immunology and Immunopathology·Allison L ZwingenbergerKit S Lam
Jan 10, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Quentin CabonClaude Carozzo
Jun 1, 2016·The Veterinary Journal·Lisa Y Pang, David J Argyle
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·A Bähr, E Wolf
Jun 8, 2012·Hematological Oncology·Laura MarconatoStefano Comazzi
Mar 20, 2013·Epilepsia·Heidrun PotschkaWolfgang Baumgärtner
Oct 15, 2013·Allergy·J Singer, E Jensen-Jarolim
Oct 12, 2013·Pigment Cell & Melanoma Research·Marc GillardCatherine André
Sep 17, 2013·Veterinary and Comparative Oncology·P DeinnocentesR Curtis Bird
May 2, 2015·Journal of Veterinary Internal Medicine·K L Wycislo, T M Fan
Mar 19, 2014·Current Opinion in Pharmacology·Sander M BotterBruno Fuchs

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Nature Biotechnology
Chand KhannaStephen J Withrow
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
K Hansen, Chand Khanna
Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Matthew Breen, Jaime F Modiano
© 2021 Meta ULC. All rights reserved