Dogs with congenital porto-systemic shunting (cPSS) and hepatic encephalopathy have higher serum concentrations of C-reactive protein than asymptomatic dogs with cPSS.

Metabolic Brain Disease
A G GowR J Mellanby

Abstract

Hepatic encephalopathy (HE) is a cause of significant morbidity and mortality in patients with liver disorders and a wide range of rodent models of HE have been described to facilitate studies into the pathogenesis and treatment of HE. However, it is widely acknowledged that no individual model perfectly mimics human HE and there is a particular need for spontaneous, larger animal models. One common congenital abnormality in dogs is the portosystemic shunt (cPSS) which causes clinical signs that are similar to human HE such as ataxia, disorientation, lethargy and occasionally coma. As inflammation has recently been shown to be associated with HE in humans, we hypothesised that inflammation would similarly be associated with HE in dogs with cPSS. To examine this hypothesis we measured C-reactive protein (CRP) in 30 healthy dogs, 19 dogs with a cPSS and no HE and 27 dogs with a cPSS and overt HE. There was a significant difference in CRP concentration between healthy dogs and dogs with HE (p < 0.001) and between dogs with HE and without HE (p < 0.05). The novel finding that there is an association between inflammation and canine HE strengthens the concept that HE in dogs with cPSS shares a similar pathogenesis to humans with HE. ...Continue Reading

References

Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter FerenciAndres T Blei
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Jul 30, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Roger F ButterworthUNKNOWN Members of the ISHEN Commission on Experimental Models of HE
Nov 17, 2009·Journal of Veterinary Internal Medicine·A G GowR J Mellanby
Jul 14, 2010·The Veterinary Journal·P D Eckersall, R Bell
Jan 26, 2011·The Veterinary Record·D SheahanP D Eckersall

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Citations

Jan 25, 2020·The Veterinary Record·Marisa da Fonseca FerreiraAdam George Gow
Oct 26, 2013·The Veterinary Record·K CrawfordA G Gow
Feb 7, 2015·PloS One·Michael S TiversRichard J Mellanby
Jun 2, 2020·Journal of Veterinary Science·Alun WilliamsRichard John Mellanby
Apr 12, 2016·Journal of Veterinary Emergency and Critical Care·Jonathan A LidburyJörg M Steiner
Jul 3, 2015·Journal of the American Veterinary Medical Association·Jonathan A LidburyJörg M Steiner
Jun 9, 2016·The Journal of Small Animal Practice·S M CraigJ A Lidbury
Feb 28, 2018·Journal of Veterinary Internal Medicine·Chantel RaghuLauren A Trepanier
Jul 3, 2013·Journal of Veterinary Internal Medicine·D KelleyC R L Webster
Aug 26, 2014·Journal of the American Veterinary Medical Association·Stephen N GreenhalghNick D Jeffery

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