DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum

Brain Research
J Ichikawa, H Y Meltzer

Abstract

The effects of (+-)-DOI (1-(2,5-dimethoxy-4-iodophenyl)-aminopropane) hydrochloride, a mixed 5-HT2A/2C receptor agonist, on the release of dopamine (DA) following D-amphetamine sulfate (AMP) or a DA D2 autoreceptor selective dose of (-)-apomorphine hydrochloride (APO), were investigated in rat striatum (STR) and nucleus accumbens (NAC), using in vivo microdialysis. AMP (1.0 mg/kg, s.c.) produced marked increases in extracellular DA levels in both the STR and the NAC whereas DOI (2.5 mg/kg, i.p.) alone had no significant effect on extracellular DA levels in either region. Pretreatment with DOI 30 min prior to AMP, further enhanced the AMP-induced increase in striatal extracellular DA levels. On the other hand, DOI pretreatment attenuated the APO (50 micrograms/kg, s.c.)-induced decrease in extracellular DA levels in the STR. Pretreatment with DOI did not affect the ability of either AMP or APO to modulate extracellular DA levels in the NAC. These results provide further evidence that 5-HT2A/2C receptors modulate the release mechanisms of DA in the STR. Possible mechanisms are discussed.

Citations

Jun 11, 1998·Alcoholism, Clinical and Experimental Research·K T Szeliga, K A Grant
Mar 19, 1999·Journal of Neuroscience Research·N K NgP T Wong
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ying QuStanley I Rapoport
Mar 18, 2011·The Biochemical Journal·Zoë BarclayRory Mitchell
Aug 14, 2020·International Journal of Molecular Sciences·Rahul BharatiyaPhilippe De Deurwaerdere
Dec 19, 2020·Neurotoxicity Research·Adam WojtasKrystyna Gołembiowska
Aug 10, 2012·The Journal of Experimental Biology·Jorge J Pérez-MaceiraManuel Aldegunde
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Aug 31, 2021·Frontiers in Neuroscience·Susanne NikolausHans-Wilhelm Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.