Doing more with less: New markers for sarcoma diagnosis and their applicability to cytology specimens

Diagnostic Cytopathology
Leslie G DoddJohann Hertel

Abstract

Sarcomas are a rare and extremely diverse set of neoplasms that are often a challenge to diagnose for pathologists. For a number of reasons, primary diagnosis of soft tissue neoplasms is increasingly being performed on small biopsy specimens including fine needle aspiration (FNA) and core needle biopsy (CNB). In the last several years, there has been a significant increase in our understanding of the molecular pathogenesis of this group of tumors. New insights into the genetic mechanisms of tumor formation have been exploited to create a new generation of diagnostic markers that are accessible to most laboratories. This review describes a number of new ancillary markers, and how they can facilitate accurate diagnosis of soft tissue neoplasms on FNA/CNB.

References

Jan 1, 1994·Annals of Surgical Oncology·M S BradyM F Brennan
Dec 16, 1998·The American Journal of Surgical Pathology·A V Vallat-DecouvelaereC D Fletcher
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·I TakanamiM Naruke
Feb 19, 2000·Diagnostic Cytopathology·Z Vesoulis, C Cunliffe
Mar 29, 2002·Cancer·Jason S GoldDaniel G Coit
Apr 3, 2003·Diagnostic Cytopathology·Anil V ParwaniSyed Z Ali
Apr 4, 2003·Cancer·Alan T MonroeNancy Price Mendenhall
May 13, 2004·Genes, Chromosomes & Cancer·Ioannis PanagopoulosFredrik Mertens
Jan 11, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Fredrik MertensIoannis Panagopoulos
Jan 27, 2007·The American Journal of Surgical Pathology·Jefferson TerryTorsten O Nielsen
May 24, 2007·British Journal of Cancer·A VirtanenA Auvinen
May 27, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joshua WeaverMarek Skacel
Jul 19, 2008·The American Journal of Surgical Pathology·Daisuke NonakaBrian P Rubin
Jul 22, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·H A DomanskiM Akerman
Nov 27, 2008·The American Journal of Surgical Pathology·Jason L HornickChristopher D M Fletcher
Jan 15, 2009·American Journal of Clinical Pathology·Laila ChbaniJean-Michel Coindre
Feb 19, 2009·Clinical Orthopaedics and Related Research·Muhammad Umar JawadSean P Scully
Mar 10, 2009·Cancer·Radhika SrinivasanRakesh Kumar Vasistha
Apr 14, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kemal KosemehmetogluAndrew L Folpe
Aug 6, 2009·The American Journal of Surgical Pathology·Ricardo S MacarencoAndre M Oliveira
Oct 8, 2009·The American Journal of Surgical Pathology·Amanda JagdisTorsten O Nielsen
Feb 25, 2010·Current Oncology·S MuzumderG K Rath
Mar 23, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenichi KohashiMasazumi Tsuneyoshi
May 25, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joshua WeaverBrian P Rubin
Feb 15, 2011·The American Journal of Surgical Pathology·Markku MiettinenIsabell Sesterhenn
Mar 19, 2011·The American Journal of Surgical Pathology·Leona A DoyleJason L Hornick
Apr 15, 2011·Advances in Anatomic Pathology·Graham W Slack, Randy D Gascoyne
May 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emely MöllerFredrik Mertens
May 17, 2011·American Journal of Clinical Pathology·Wai Chin FooJason L Hornick
Jun 17, 2011·The American Journal of Surgical Pathology·Javier A LauriniAndrew L Folpe
Jun 23, 2011·Diagnostic Cytopathology·Adarsh BarwadAshim Das

❮ Previous
Next ❯

Citations

Nov 13, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Andrea RonchiImmacolata Cozzolino
Jan 27, 2019·Molecular and Clinical Oncology·Xiaoyan LiYinghong Yang
Jul 6, 2020·Journal of the American Society of Cytopathology : JASC·Meagan ChambersDarcy A Kerr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.