Doing no harm? Adverse events in a nation-wide cohort of patients with multidrug-resistant tuberculosis in Nigeria

PloS One
Yohanna Kamabi AvongPatrick Sunday Dakum

Abstract

Adverse events (AEs) of second line anti-tuberculosis drugs (SLDs) are relatively well documented. However, the actual burden has rarely been described in detail in programmatic settings. We investigated the occurrence of these events in the national cohort of multidrug-resistant tuberculosis (MDR-TB) patients in Nigeria. This was a retrospective, observational cohort study, using pharmacovigilance data systematically collected at all MDR-TB treatment centers in Nigeria. Characteristics of AEs during the intensive phase treatment were documented, and risk factors for development of AEs were assessed. Four hundred and sixty patients were included in the analysis: 62% were male; median age was 33 years [Interquartile Range (IQR):28-42] and median weight was 51 kg (IQR: 45-59). Two hundred and three (44%) patients experienced AEs; four died of conditions associated with SLD AEs. Gastro-intestinal (n = 100), neurological (n = 75), ototoxic (n = 72) and psychiatric (n = 60) AEs were the most commonly reported, whereas ototoxic and psychiatric AEs were the most debilitating. Majority of AEs developed after 1-2 months of therapy, and resolved in less than a month after treatment. Some treatment centers were twice as likely to report A...Continue Reading

References

Jan 1, 1986·British Journal of Clinical Pharmacology·J P Griffin
Mar 28, 1998·British Journal of Clinical Pharmacology·N MooreM Mabille
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Oct 28, 1999·PharmacoEconomics·T J WhiteJ P Rho
Jun 20, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robert C NelsonVictor Gogolak
Jan 10, 2008·The Journal of Infectious Diseases·Jason R AndrewsUNKNOWN Tugela Ferry Care and Research (TF CARES) Collaboration
Jan 10, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elena Lopez-GonzalezAdolfo Figueiras
Dec 17, 2009·Pharmacoepidemiology and Drug Safety·J O Ohaju-Obodo, O I Iribhogbe
May 16, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M W CarrollC E Barry
Jun 8, 2012·The New England Journal of Medicine·Maria Tarcela GlerCharles D Wells
Aug 7, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Evans SagwaAukje K Mantel-Teeuwisse
Dec 7, 2013·The International Journal of Risk & Safety in Medicine·Adeline OsakweIretiola Fajolu

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Citations

Oct 23, 2015·Tropical Medicine & International Health : TM & IH·Joseph S CavanaughJames D Heffelfinger
Jan 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Jun 18, 2019·Infectious Diseases of Poverty·Daniel Chukwuemeka Ogbuabor, Obinna Emmanuel Onwujekwe
Aug 20, 2019·Health and Quality of Life Outcomes·Ammar Ali Saleh Jaber, Baharudin Ibrahim
Oct 13, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Edine TiemersmaMichael Kimerling

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