DOLAMA study: Effectiveness, safety and pharmacoeconomic analysis of dual therapy with dolutegravir and lamivudine in virologically suppressed HIV-1 patients

Medicine
Carmen Hidalgo-TenorioJuan Pasquau

Abstract

Dolutegravir (DTG) has shown effectiveness in combination with rilpivirine in with experience of antiretroviral therapy (ART) and with 3TC in naïve patients (GEMINI trial). The main objectives of this real-life study were to analyze the effectiveness and safety of 3TC plus DTG in virologically suppressed HIV-1 patients and to conduct a pharmacoeconomic analysis.We conducted an observational, retrospective and multicenter study of HIV+ patients pretreated for at least 6 months with ART that was then simplified to 3TC + DTG for any reason. We gathered data on viral loads (VLs) during exposure to the DT, calculating the rate with VL < 50 copies/mL at week 48, and on associated adverse effects.The 177 HIV+ patients were collected, 77.4% male, with average age of 48.5 years and mean count of 252.2cell/μL CD4+ nadir lymphocytes; 96.6% had VL < 50 copies/mL and 674 cells/μL CD4+ lymphocytes. Median time since HIV diagnosis was 15 years, and median ART duration was 13 years, and 34.5% of patients were on mono- or dual-therapy before the switch. At week 48, 82.4% of patients had VL < 50 cop/μL using an intention-to-treat (ITT) analysis, 89.6% according to mITT, and 96.7% according to Per-Protocol analysis. 3.3% patients had virological ...Continue Reading

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Citations

Feb 19, 2020·Expert Review of Anti-infective Therapy·Arturo CicculloSimona Di Giambenedetto
Mar 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alberto BorghettiSimona Di Giambenedetto
Aug 28, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Arturo CicculloGianmaria Baldin
Oct 16, 2021·The Journal of Antimicrobial Chemotherapy·Colin DeschanvresUNKNOWN Dat’AIDS Study Group

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Software Mentioned

PADDLE
GEMINI

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