Domain-Specific Diaschisis: Lesions to Parietal Action Areas Modulate Neural Responses to Tools in the Ventral Stream

Cerebral Cortex
Frank E GarceaBradford Z Mahon

Abstract

Neural responses to small manipulable objects ("tools") in high-level visual areas in ventral temporal cortex (VTC) provide an opportunity to test how anatomically remote regions modulate ventral stream processing in a domain-specific manner. Prior patient studies indicate that grasp-relevant information can be computed about objects by dorsal stream structures independently of processing in VTC. Prior functional neuroimaging studies indicate privileged functional connectivity between regions of VTC exhibiting tool preferences and regions of parietal cortex supporting object-directed action. Here we test whether lesions to parietal cortex modulate tool preferences within ventral and lateral temporal cortex. We found that lesions to the left anterior intraparietal sulcus, a region that supports hand-shaping during object grasping and manipulation, modulate tool preferences in left VTC and in the left posterior middle temporal gyrus. Control analyses demonstrated that neural responses to "place" stimuli in left VTC were unaffected by lesions to parietal cortex, indicating domain-specific consequences for ventral stream neural responses in the setting of parietal lesions. These findings provide causal evidence that neural specific...Continue Reading

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Citations

Nov 3, 2020·Cerebral Cortex Communications·Frank E GarceaLaurel J Buxbaum
Apr 27, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lénia AmaralJorge Almeida
Jun 9, 2021·Scientific Reports·Artur PilacinskiJorge Almeida
Jun 21, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Daniela ValérioJorge Almeida
Jul 12, 2021·Brain Structure & Function·Giulia Malfatti, Luca Turella

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