Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

Nature
R F DoolittleA Sancar

Abstract

The ABC excision nuclease of Escherichia coli is an ATP-dependent DNA repair enzyme composed of three protein subunits, UvrA, UvrB and UvrC. The DNA sequences of all three genes have been reported. UvrA, the component that binds directly to the DNA, and UvrB, which attaches itself to the UvrA-DNA complex, both contain consensus sequences though to be diagnostic of ATP-binding sites, although the UvrC sequence does not. We now report that a computer analysis of the UvrA sequence has revealed an unusual series of internal duplications centering around putative metal-binding sites which may be involved in the interaction with DNA. We also find a strong evolutionary relationship to a family of prokaryotic membrane-associated active-transport proteins.

References

Mar 25, 1986·Nucleic Acids Research·E ArikanA Sancar
Jan 1, 1984·Journal of Molecular Evolution·D F FengR F Doolittle
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A C HobsonG F Ames
Nov 25, 1982·Nucleic Acids Research·E GilsonM Hofnung
Jun 11, 1984·Nucleic Acids Research·G B SancarW D Rupp
Jun 5, 1981·Journal of Molecular Biology·J J Dunn, F W Studier

❮ Previous
Next ❯

Citations

Sep 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N SaitohW C Earnshaw
Dec 1, 1994·Journal of Molecular Evolution·E LittleR F Doolittle
Dec 1, 1987·Molecular & General Genetics : MGG·D R Gill, G P Salmond
Feb 1, 1988·Journal of Bioenergetics and Biomembranes·G F Ames
Aug 1, 1990·Journal of Bioenergetics and Biomembranes·C F HigginsM P Gallagher
Aug 3, 1988·Biochimica Et Biophysica Acta·G BradleyV Ling
Jun 2, 2005·Mutation Research·Bennett Van HoutenCaroline Kisker
Sep 9, 2000·FEMS Microbiology Reviews·M BraibantJ Content
Mar 30, 2002·Advanced Drug Delivery Reviews·Eric Y ZhangPeter W Swaan
Dec 22, 1999·Mutation Research·J A Eisen, P C Hanawalt
Feb 7, 2012·Nature Structural & Molecular Biology·Danaya PakotipraphaDavid Jeruzalmi
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D K Orren, A Sancar
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L BishopG F Ames
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J H ToneyS J Lippard
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L S GreenA R Grossman
Jul 11, 2006·The Journal of Biological Chemistry·Deborah L CroteauBennett Van Houten
Nov 25, 1987·Nucleic Acids Research·M van DuinJ H Hoeijmakers
Jun 24, 1988·Nucleic Acids Research·M van DuinJ H Hoeijmakers
Nov 11, 1989·Nucleic Acids Research·A E Gorbalenya, E V Koonin
Sep 2, 1998·Nucleic Acids Research·W L de LaatJ H Hoeijmakers
Feb 13, 2001·Nucleic Acids Research·Pierre-Henri L Gaillard, R D Wood
Mar 5, 2013·Cold Spring Harbor Perspectives in Biology·Caroline KiskerBennett Van Houten
Apr 1, 1990·Molecular Microbiology·D R Gill, G P Salmond
Jul 29, 1994·Annals of the New York Academy of Sciences·B Van Houten, A McCullough
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Dea Slade, Miroslav Radman
Jun 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Amy L DavidsonJue Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.