Domains and correlates of clinical balance impairment associated with Huntington's disease

Gait & Posture
Jesse V JacobsFay B Horak

Abstract

This study sought to (a) determine the domains of clinical balance impairments associated with Huntington's disease (HD), and (b) evaluate associations between balance test scores and other disease-related impairments. Eighteen subjects with genetically definite HD and 17 age-matched control subjects were evaluated on the Mini-BESTest for their clinical balance impairments as well as the Unified HD Rating Scale (UHDRS) motor and total functional capacity scales, Activity-Specific Balance Confidence (ABC) Scale-short form, Montreal Cognitive Assessment (MoCA), and Symbol Digit Modalities Test (SDMT). Results showed that subjects with HD exhibited significantly lower total Mini-BESTest scores than subjects without HD (mean (95% CI)=76 (64-87)% with HD, 98 (96-99)% without HD; p=0.0011). Mini-BESTest item scores were significantly lower for subjects with HD on one-leg stance, postural responses, standing with eyes closed on foam, and dual-task timed up-and-go. Mini-BESTest scores significantly correlated with UHDRS motor (r(2)=0.68; p=0.00003) and total functional capacity (r(2)=0.75; p=0.000006) scores as well as with scores on the ABC short form (r(2)=0.45; p=0.0024), SDMT (r(2)=0.42; p=0.0036), and MoCA (r(2)=0.23; p=0.046) ass...Continue Reading

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Citations

Jun 20, 2017·Journal of Neurologic Physical Therapy : JNPT·Nora E FritzUNKNOWN Members of the Physiotherapy Working Group of the European Huntingtonʼs Disease Network
Oct 27, 2018·Movement Disorders Clinical Practice·Tiago A MestreUNKNOWN Members of the MDS Committee on Rating Scales Development
Jan 23, 2021·Physical Therapy·Alvaro ReyesTravis M Cruickshank

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