PMID: 8986838Dec 24, 1996Paper

Domains of P2X receptors involved in desensitization

Proceedings of the National Academy of Sciences of the United States of America
P WernerR A North

Abstract

ATP-gated ion channels (P2X receptors) are abundantly expressed in both neuronal and nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP shows marked desensitization in some tissues but not others. Currents induced by ATP in Xenopus oocytes expressing cloned P2X1 (or P2X3) receptor had strong desensitization, whereas currents in cells expressing P2X2 receptors desensitized relatively little (90% vs. 14% decline of current in a 10-s application). In chimeric receptors, substitution into the P2X1 receptor of either one of two 34-residue segments from the P2X2 receptor removed the desensitization; these segments included the first or the second hydrophobic domain. In contrast, desensitization was introduced into the P2X2 receptor only by providing both these segments of the P2X1 (or P2X3) receptor. This suggests that desensitization requires interaction between the two hydrophobic domains of the receptor, and supports the view that these are membrane-spanning segments.

References

Jun 11, 1992·Nature·R J EvansA Surprenant
May 1, 1995·Trends in Neurosciences·A SurprenantR A North
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L YakelR A North
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Citations

Sep 1, 2000·Drug Development Research·Liping ChenKenneth A Jacobson
Apr 12, 2006·Pflügers Archiv : European journal of physiology·Jonathan A RobertsRichard J Evans
Mar 26, 2011·Purinergic Signalling·Eva-Verena BongartzRalf Hausmann
May 2, 2012·Purinergic Signalling·Karina Kaczmarek-HájekAnnette Nicke
Oct 24, 2001·European Journal of Pharmacology·T NotoK Kikkawa
Jul 16, 2003·European Journal of Pharmacology·Claudio CoddouJ Pablo Huidobro-Toro
Jul 8, 1999·European Journal of Pharmacology·S TakanoT Ono
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 31, 1998·Hearing Research·M S ParkerP L Deininger
Jun 1, 1997·Current Opinion in Neurobiology·R A North, E A Barnard
Nov 15, 2003·Autonomic Neuroscience : Basic & Clinical·Guo Jun LiuMaxwell R Bennett
Jun 26, 1998·British Journal of Pharmacology·C Chen, R P Bobbin
Oct 27, 2011·The Journal of Biological Chemistry·Rebecca C Allsopp, Richard J Evans
Apr 30, 2003·The Journal of General Physiology·Jürgen Rettinger, Günther Schmalzing
Feb 28, 2007·The Journal of General Physiology·Damien S K Samways, Terrance M Egan
Dec 6, 2001·Neuroreport·M R Bennett, J A Barden
Dec 21, 2012·Molecular Pharmacology·R Alan North, Michael F Jarvis
Mar 19, 2014·International Journal of Molecular Sciences·Luiz Anastacio AlvesMônica Santos de Freitas
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liam E BrowneR Alan North
Feb 15, 2016·Purinergic Signalling·Zhuoran Hou, Jun Cao
Oct 12, 1999·The Journal of Physiology·F M SmithR D Murrell-Lagnado
May 23, 1998·The Journal of Physiology·T Capiod
Jul 22, 2006·The Journal of Physiology·Yuichiro Fujiwara, Yoshihiro Kubo
Dec 5, 2012·Trends in Biochemical Sciences·Ruotian JiangThomas Grutter
Aug 24, 2005·The European Journal of Neuroscience·Teresa A BrosenitschGregory D Funk
Oct 16, 2007·British Journal of Pharmacology·J A SimR A North
Jun 26, 2012·British Journal of Pharmacology·Y BhargavaA Mourot

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