Dominance of E. coli phagocytosis over LPS in the inflammatory response of microglia

Journal of Neuroimmunology
Vishanthan SivagnanamL C Schlichter

Abstract

CNS bacterial infections are prevalent in neonates, the immune-compromised and elderly. During peripheral infections, macrophages employ multiple pattern recognition receptors (PRRs) to respond to pathogens, but less is known about brain microglia. We assessed microglial expression of PRRs, compared responses to whole E. coli and LPS, and tested the hypothesis that bacteria modulate the response to LPS. LPS increased the microglial phagocytic capacity, and changed expression of CD14, CR3, Fcgr1, Fcgr3a, TLR4, MARCO, MHCII, NOD2, TLR9 and SR-A, differently from stimulation with whole E. coli. Importantly, when added with LPS, E. coli dominated the microglial responses for 11/13 genes examined.

References

Jul 1, 1995·The Journal of Infectious Diseases·B GårdlundB Wretlind
Apr 1, 1997·Neurochemistry International·F S SilversteinJ Szaflarski
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Mar 29, 2001·Biology of the Neonate·E Saliba, A Henrot
Oct 31, 2002·The European Journal of Neuroscience·Annemarie LedeboerAnne-Marie Van Dam
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jul 15, 2003·Clinical Microbiology Reviews·Edwin S Van AmersfoortJohan Kuiper
Dec 31, 2003·The Journal of Experimental Medicine·Sean E DoyleGenhong Cheng
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Martin L CrossLinley M Fray
Dec 28, 2004·International Journal for Parasitology·Yasuhiro SuzukiTakane Kikuchi
Jun 15, 2005·Annual Review of Biochemistry· InoharaGabriel Nuñez
Aug 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher B FordyceLyanne C Schlichter
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vikas KaushalLyanne C Schlichter
Feb 24, 2007·Cellular and Molecular Neurobiology·Atsushi YamauchiYasufumi Kataoka
Apr 3, 2007·PLoS Pathogens·Anat A HerskovitsDaniel A Portnoy
Oct 9, 2007·Brain, Behavior, and Immunity·Pamela A CarpentierStephen D Miller
Oct 12, 2007·The European Journal of Neuroscience·Guillaume DucharmeLyanne C Schlichter
Feb 13, 2008·Journal of Neuroendocrinology·A MouihateQ J Pittman
Nov 26, 2008·Clinics in Perinatology·Olaf Dammann, T Michael O'Shea
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Mar 24, 2009·Annual Review of Immunology·Richard M Ransohoff, V Hugh Perry
May 1, 2009·Nature Cell Biology·Igor E Brodsky, Ruslan Medzhitov
Aug 6, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carol A Colton

❮ Previous
Next ❯

Citations

Apr 25, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·B-S LiuL C Schlichter
Jun 22, 2013·Journal of Neuroinflammation·Starlee Lively, Lyanne C Schlichter
Aug 10, 2012·Journal of Neuroinflammation·Catherine VincentLyanne C Schlichter
Nov 20, 2012·Journal of Neuroinflammation·Tamjeed A SiddiquiLyanne C Schlichter
Mar 25, 2016·Journal of Neuroinflammation·Tamjeed A SiddiquiLyanne C Schlichter
Mar 10, 2017·International Journal of Molecular Sciences·Jillian C Nissen
Aug 9, 2018·Frontiers in Cellular Neuroscience·Starlee Lively, Lyanne C Schlichter
Sep 11, 2020·BioMed Research International·Hao YuShiqing Feng
Dec 14, 2018·Frontiers in Cellular Neuroscience·Starlee LivelyLyanne C Schlichter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.