PMID: 11912011Mar 26, 2002Paper

Dominant expression of CXCR3 is associated with induced expression of IP-10 at hapten-challenged sites of murine contact hypersensitivity: a possible role for interferon-gamma-producing CD8(+) T cells in IP-10 expression

Journal of Dermatological Science
Atsushi TokurikiY Tokura

Abstract

Murine contact hypersensitivity is elicited as a consequence of immunologic reactions triggered by skin-applied antigen, interactions among Langerhans cells, T cells, keratinocytes and mast cells, and a variety of chemokines generated by cellular interactions. In this study, we sensitized and challenged BALB/c mice with hapten, dinitrofluorobenzene or picryl chloride, and examined the expressions of mRNA for chemokines and their receptors by reverse transcription-polymerase chain reaction in the skin of elicited earlobes. CXC chemokines, IP-10 and Mig, were transcribed 24-48 h after challenge. This was associated with the expression of their agonistic receptor CXCR3, while mRNA for TARC and MDC, and their receptor CCR4 were not detected. Since CXCR3 and CCR4 are expressed preferentially on types 1 (Th1/Tc1) and 2 (Th2) T cells, respectively, the results suggested that the former type of T cells predominantly infiltrate at the elicited sites. Immune lymph node cells of the sensitized mice also expressed mRNA for CXCR3 but not CCR4 with concomitant transcription of interferon-gamma (IFN-gamma) but not interleukin-4 subsequent to challenge. The percentage of lymph node CD8(+) T cells was increased from 16% in naive mice to 30-50% ...Continue Reading

References

Jan 26, 1991·Lancet·J N BarkerB J Nickoloff
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Aug 15, 1998·Archives of Dermatological Research·D M BoorsmaT J Stoof
Mar 2, 1999·The Journal of Experimental Medicine·J KehrenJ F Nicolas
Jul 9, 1999·Biochimica Et Biophysica Acta·C P TensenR Willemze
Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann

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Citations

Feb 21, 2004·International Immunopharmacology·Gaku MitsuiMasatoshi Kato
May 2, 2003·American Journal of Respiratory and Critical Care Medicine·Stephanie SénéchalBenoît Wallaert
Feb 23, 2008·The American Journal of Pathology·Sabita RanaGary Mark Halliday
Jun 7, 2005·Acta Neuropathologica·Boel De PaepeJan L De Bleecker
Nov 22, 2014·Journal of Immunotoxicology·Mitchell ThornMark Collinge
Nov 24, 2007·Experimental Dermatology·Yoshiki TokuraKenji Kabashima
Mar 10, 2009·Cytokine & Growth Factor Reviews·Alfons Billiau, Patrick Matthys
Jun 28, 2011·The American Journal of Pathology·Yoshihiro YamamotoTakahiro Satoh
Jun 26, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Jeffrey S SmithAmber Reck Atwater
Dec 14, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anne Deen Christensen, Claus Haase
May 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiraku SugaShinichi Sato
Sep 29, 2011·Molecular Immunology·Yuki MatsushimaHiroo Yokozeki

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