Dominant inheritance of large molecular weight immunoreactive glucagon

The Journal of Clinical Investigation
J P PalmerJ W Ensinck

Abstract

Plasma from some individuals contains substances which are reactive with glucagon antiserum, are larger than 3,500-dalton glucagon, and have been proposed as possible precursors of glucagon. We have evaluated three generations of a kindred in which 9 of 15 members evaluated had elevated plasma levels of large molecular weight immunoreactive glucagon (L-IRG) with an average concentration of 822 pg/ml. The distribution of individuals with elevated L-IRG levels in this pedigree is consistent with autosomal dominant inheritance. Gel filtration of plasma revealed that all affected family members had excessive amounts of two L-IRG peaks, one with a molecular weight of approximately 9,000 daltons and another in the 10,000 to 20,000-dalton range. Oral glucose tolerance tests were nondiabetic and elicited a fall in L-IRG levels, whereas L-IRG concentrations rose dramatically during the infusion of arginine. These L-IRG species may be precursors of 3,500-DALTON GLUCAGON AND MAY BE ELEVATED in this kindred because of an inherited defect in either their synthesis or degradation.

References

May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·I ValverdeR H Unger
Jul 29, 1976·The New England Journal of Medicine·D N DanforthL Recant
Mar 10, 1977·The New England Journal of Medicine·G Boden, O E Owen
Apr 22, 1976·The New England Journal of Medicine·K H GabbayA H Rubenstein
Apr 8, 1975·Biochemistry·A C TrakatellisP Gardiki-Kouidou
Jul 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B D NoeJ S Najarian
Feb 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G C WeirD B Martin
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S F KukuA H Rubenstein
Apr 22, 1976·The New England Journal of Medicine·D F Steiner
Jul 6, 1974·Lancet·C N MallinsonB Cox
Nov 1, 1974·The Journal of Clinical Investigation·R M WalterJ W Ensinck
Jun 23, 1966·The New England Journal of Medicine·M H McGavranM E Levin
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J I Starr, A H Rubenstein
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H S Tager, D F Steiner
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A K Tung
Dec 1, 1974·The Journal of Clinical Endocrinology and Metabolism·I ValverdeJ Marco

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Citations

Jun 28, 1982·Life Sciences·R M WalterJ W Ensinck
Dec 1, 1981·Current Problems in Cancer·F Montenegro-Rodas, N A Samaan
Aug 1, 1984·Metabolism: Clinical and Experimental·K TanakaH Yoshida
Dec 1, 1979·Australian and New Zealand Journal of Medicine·F P Alford, D J Chisholm
Jul 1, 1979·Clinics in Endocrinology and Metabolism·J J Holst
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Apostolos V Tsolakis, Eva T Janson
May 1, 1979·Metabolism: Clinical and Experimental·J P PalmerJ W Ensinck
Jan 1, 1984·Critical Reviews in Oncology/hematology·C J LipsC B Lamers

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