PMID: 9008719Dec 20, 1996Paper

Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide

Mutation Research
W M GenerosoM D Shelby

Abstract

The hypothesis that acrylamide induces dominant lethal mutations and heritable translocations in male mice, not through direct adduction, but by conversion to the reactive epoxide, glycidamide, was investigated. Three studies, namely, induction of dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis in spermatids, which were conducted earlier in this laboratory for acrylamide, were also performed for glycidamide to determine its mutagenic properties and to compare responses. Results of these studies are consistent with the proposal that in vivo conversion to glycidamide is responsible for the mutagenicity of acrylamide in male mice.

References

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Citations

Jan 28, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kellie O RobinsonLisa Stubbs
Mar 14, 2002·Mutation Research·Anand M Jha, Mithilesh K Bharti
Jan 1, 2003·Reproductive Toxicology·Rochelle W Tyl, Marvin A Friedman
May 12, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·J H Exon
Dec 1, 2007·Journal of Toxicology and Environmental Health. Part a·Katherine WalkerGary Ginsberg
Jun 29, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rui-Sheng WangNan Mei
Jan 26, 2005·Mutation Research·Daniel R DoergeFrederick A Beland
Feb 1, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E DybingP Verger
Oct 27, 2004·Chemico-biological Interactions·Janusz BlasiakAgnieszka Czechowska
Oct 22, 2005·Toxicology and Applied Pharmacology·Daniel R DoergeMona I Churchwell
May 20, 2015·Mutation Research·Aimee L Katen, Shaun D Roman
Jan 1, 2011·Saudi Journal of Biological Sciences·Hind Abdullah Seed Alzahrani
Feb 25, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeanne MansonPeter Working
Jun 16, 2005·Environmental and Molecular Mutagenesis·Mugimane G ManjanathaDaniel R Doerge
Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Francesco Marchetti, Andrew J Wyrobek
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham
Nov 5, 2010·Toxicology Mechanisms and Methods·Yong CuiZiyuan Chen
Mar 21, 1998·Methods : a Companion to Methods in Enzymology·L StubbsW Generoso

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