Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study

The Lancet Global Health
Mayowa Owolabias part of H3Africa Consortium

Abstract

Sub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce the stroke burden in sub-Saharan Africa is available. We aimed to identify and characterise the effect of the top modifiable risk factors for stroke in sub-Saharan Africa. The Stroke Investigative Research and Educational Network (SIREN) study is a multicentre, case-control study done at 15 sites in Nigeria and Ghana. Cases were adults (aged ≥18 years) with stroke confirmed by CT or MRI. Controls were age-matched and gender-matched stroke-free adults (aged ≥18 years) recruited from the communities in catchment areas of cases. Comprehensive assessment for vascular, lifestyle, and psychosocial factors was done using standard instruments. We used conditional logistic regression to estimate odds ratios (ORs) and population-attributable risks (PARs) with 95% CIs. Between Aug 28, 2014, and June 15, 2017, we enrolled 2118 case-control pairs (1192 [56%] men) with mean ages of 59·0 years (SD 13·8) for cases and 57·8 years (13·7) for controls. 1430 (68%) had ischaemic stoke, 682 (32%) had haemorrhagic stroke, and six (<1%) had discrete ischae...Continue Reading

Citations

Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Yogeshwar V KalkondeVladimir Hachinski
May 31, 2019·Journal of the American Heart Association·Abiodun M AdeoyeMayowa Owolabi
Nov 23, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Fred Stephen SarfoUNKNOWN PINGS Team
Dec 7, 2019·Circulation. Cardiovascular Quality and Outcomes·Mayowa O OwolabiBruce Ovbiagele
Nov 27, 2019·The Journal of Clinical Hypertension·Norm R C CampbellDaniel T Lackland
Feb 7, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Rufus AkinyemiMayowa Owolabi
Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Graeme J Hankey
Aug 23, 2020·Journal of Magnetic Resonance Imaging : JMRI·Seema S BhatSairam Geethanath
Aug 21, 2020·The Journal of Clinical Hypertension·Nana Kwame Ayisi-BoatengFred Stephen Sarfo
Jun 23, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hsu-Wen TsengKylie A Alexander
Dec 12, 2018·International Journal of Epidemiology·Mayowa O OwolabiUNKNOWN as members of the CVD Working Group of the H3Africa Consortium
May 28, 2019·The Journal of Clinical Hypertension·Fred Stephen SarfoBruce Ovbiagele
Aug 27, 2019·Frontiers in Neurology·Fode A CisseGilles Naeije
Sep 14, 2019·Nutritional Neuroscience·Shahram Arsang-JangNizal Sarrafzadegan
Sep 2, 2020·International Journal of Mental Health Systems·Waleed M Sweileh
Mar 19, 2019·Stroke; a Journal of Cerebral Circulation·Albert AkpaluMayowa Owolabi
Sep 5, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Kolawole W WahabAyodele B Omotoso
Oct 20, 2020·Journal of Geriatric Psychiatry and Neurology·Akin OjagbemiBruce Ovbiagele
Oct 27, 2020·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindGeorge Howard
Dec 31, 2020·International Psychogeriatrics·Akin OjagbemiOlusegun Baiyewu
Oct 24, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fred Stephen Sarfo, Bruce Ovbiagele
Jan 17, 2021·Nature Reviews. Neurology·Rufus O Akinyemi, Michael Brainin
Jan 24, 2021·The Journal of Clinical Hypertension·Onoja M AkpaUNKNOWN SIREN Study as part of the H3Africa Consortium
Feb 3, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Thierry AdoukonouPhilippe Lacroix
Apr 11, 2020·Annals of Medicine and Surgery·Ginenus FekaduAyantu Kebede
Feb 25, 2021·European Journal of Preventive Cardiology·Paul OlowoyoMayowa Owolabi
Mar 1, 2021·Lancet·Jeyaraj D PandianJackie Bosch
Oct 1, 2018·Journal of the Neurological Sciences·Fred Stephen SarfoBruce Ovbiagele
Feb 25, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fred S SarfoUNKNOWN PINGS Study Investigators
Mar 25, 2021·Journal of the Neurological Sciences·Aparna NutakkiDeanna Saylor
Mar 28, 2021·Journal of the Neurological Sciences·Fred Stephen SarfoBruce Ovbiagele
Jan 2, 2019·Journal of the Neurological Sciences·Fred Stephen SarfoBruce Ovbiagele
Mar 23, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Thierry AdoukonouPhilippe Lacroix

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