PMID: 1194856Dec 1, 1975Paper

Dominant nonresponsiveness in the induction of autoimmunity to liver-specific F antigen

The Journal of Experimental Medicine
D M Silver, D P Lane

Abstract

The liver-specific F antigen, although not an autoimmunogen, can induce the production of autoantibodies in responder strains. The ability to respond is under the control of two genes, one linked to the H-2 locus of mice, the other not. Responders possessing both genes produce high anti-F titers, while the H-2-linked gene alone permits a significant but low antibody response. (Responder X nonresponder) F1 hybrids derived from parents possessing identical F molecules are nonresponders, in contrast with the dominance of responsiveness in Ir gene systems. The presence of the H-2 locus from nonresponders appears involved in the inability to respond. This is discussed in terms of self-tolerance and suppression.

References

Jan 21, 1972·Science·B Benacerraf, H O McDevitt
Mar 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·R Hunter
Jan 1, 1969·International Archives of Allergy and Applied Immunology·B CinaderD Naylor

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Citations

Feb 10, 2000·Springer Seminars in Immunopathology·N A MitchisonB Müller
Jan 1, 1981·Immunogenetics·D M Silver, D P Lane
May 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y MoriK Okuda
Apr 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y MoriK Okuda
Jul 12, 2002·Arthritis Research·Michael L Dustin
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Müller, A Mitchison
Aug 1, 1979·Tissue Antigens·D M Silver

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