PMID: 7539830Feb 1, 1995Paper

Dominant replication of either virus in dual infection with hepatitis viruses B and C

Journal of Medical Virology
K KoikeS Iino

Abstract

To characterize the state of dual infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), HBV-DNA and HCV-RNA levels were determined by spot hybridization or polymerase chain reaction in the sera of patients who were positive for both hepatitis B surface antigen and HCV antibody. Among 27 patients who showed evidence of double infection, 21 (77.8%) had detectable levels of only either HBV or HCV genome in their sera, 2 (7.4%) showed none of the viral genomes, and 4 (14.8%) had both HBV-DNA and HCV-RNA. In the 4 patients with both HBV-DNA and HCV-RNA, the titers of HCV-RNA or HBV-DNA were lower than those in the patients with HCV-RNA or HBV-DNA alone. In some patients with chronic hepatitis, the viruses appeared to replicate in turn in the course of the disease. These results indicate that the viruses show alternating dominance in replication in most of the patients who have dual infection with HBV and HCV, probably due to interference of the viruses.

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Citations

Mar 3, 2006·Current Gastroenterology Reports·James S ParkDouglas T Dieterich
Sep 24, 1998·Transplantation Proceedings·H ZylberbergS Pol
Apr 16, 1998·Journal of Hepatology·J P ZarskiD Dhumeaux
Apr 17, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K Koike
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Dar-In TaiJuei-Low Sung
Oct 6, 2011·Archives of Pathology & Laboratory Medicine·Rachel Hudacko, Neil Theise
Feb 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edmund J Bini, Ponni V Perumalswami
May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E KhattabF Zoulim
Aug 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yen-Tsung HuangChien-Jen Chen
Mar 16, 2017·Epidemiology·Yen-Tsung Huang, Hwai-I Yang
Feb 10, 1998·International Journal of Cancer. Journal International Du Cancer·F DonatoM Puoti
May 2, 2002·Journal of Gastroenterology and Hepatology·Kazuhiko KoikeSatoshi Kimura
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Dec 20, 2018·Statistics in Medicine·Shu-Hsien Cho, Yen-Tsung Huang

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