PMID: 2110506May 4, 1990Paper

Dominantly inherited expression of BID, an invariant undiversified T cell receptor delta chain

Cell
G K Sim, A Augustin

Abstract

In BALB/c lung and lymph node gamma delta T cells, a large fraction of the expressed V delta 5 genes consist of an invariant sequence, BID (for BALB/c invariant delta). BID results from a direct joining of the V delta 5, D delta 2, and J delta 1 segments, which conserve their complete germline coding sequences. In C57BL/6 (H-2b) mice, where identical and functional segments are present in the germline, BID is absent. It appears that BID+ gamma delta T cells are positively selected by factors encoded outside of the classical MHC region, as indicated by their dominance in F1(C57BL/6 x BALB/c) and in BALB.B (H-2b) mice. Additional observations, including the expression of BID in BALB/c nu/nu but not in C57BL/6 nu/nu mice, suggest that the expansion of BID+ T cells essentially occurs extrathymically.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K ItoS Tonegawa
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M BonnevilleS Tonegawa
Apr 14, 1983·Nature·S Tonegawa

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Citations

Dec 15, 1995·Microscopy Research and Technique·J Pudney
Jan 1, 1992·Immunologic Research·L Lefrançois
Apr 1, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Willi K Born, Rebecca L O'Brien
Mar 3, 2007·Journal of Clinical Immunology·Willi K BornRebecca L O'Brien
May 1, 1994·Biophysical Chemistry·T Yoshizawa
Sep 1, 1990·Research in Immunology·A Augustin, G K Sim
Apr 1, 1992·Current Opinion in Immunology·W Haas, S Tonegawa
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BandeiraS Tonegawa
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KosekiM Taniguchi
Feb 1, 1991·The Journal of Experimental Medicine·B L RellahanL A Matis
Sep 1, 1991·The Journal of Experimental Medicine·K UyemuraR L Modlin
Nov 1, 1993·The Journal of Experimental Medicine·R RajasekarA Augustin
Apr 1, 1991·Immunological Reviews·J A BluestoneL A Matis
Jan 1, 1994·International Reviews of Immunology·Y MakinoM Taniguchi
Sep 1, 1992·European Journal of Immunology·M H DelfauB Grandchamp
Sep 17, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Jonas Schreyögg, Markus M Grabka
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Willi K BornRebecca L O'Brien
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Youn-Soo HahnWilli K Born
Nov 5, 2020·Immunological Reviews·Maria PapadopoulouDavid Vermijlen

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