Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3

The Journal of Organic Chemistry
Lisi HeGavin Chit Tsui

Abstract

A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF3] reagent is achieved. Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF3 is the inexpensive industrial waste fluoroform.

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Citations

Nov 15, 2018·Organic & Biomolecular Chemistry·Naila IqbalEun Jin Cho
May 24, 2019·Angewandte Chemie·Jia-Xiang XiangFeng-Ling Qing
Jul 8, 2020·Chemistry : a European Journal·Velayudham RamadossYahui Wang
Aug 23, 2019·Organic Letters·Muhammad IsrarHongli Bao
Feb 2, 2018·Organic Letters·Xinkan Yang, Gavin Chit Tsui
Feb 3, 2018·The Journal of Organic Chemistry·Meng-Yang ChangHeui-Sin Wang
Oct 31, 2021·Angewandte Chemie·Mélodie BirepinteJean-François Paquin

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