Domino Liver Transplant in Maple Syrup Urine Disease: Technical Details of Cases in Which the First Surgery Involved a Living Donor

Transplantation
Karina M O RodaJoao Seda Neto

Abstract

Data describing the technical aspects of living donor (LD) domino liver transplantation (DLT) in maple syrup urine disease (MSUD) are limited. The largest published series includes only 3 cases. One great challenge of this procedure is to ensure adequate vascular stumps for the LD, the MSUD patient, and the recipient of the domino graft. Here, we describe our experience in 11 cases of LD-DLT in MSUD, highlighting the technical aspects of LD-DLT. From September 2012 to September 2017, 11 patients with MSUD underwent LD liver transplantation at our institution, and MSUD livers were used as domino grafts in 11 children. (1) MSUD patients: 10 patients received a left lateral segment. The donor's left hepatic vein (HV) was anastomosed to the confluence of the recipient's 3 HVs. No vascular grafts (VG) were required for portal vein (PV) anastomosis. Single arterial anastomosis was performed with microsurgery in 10 of 11 patients. (2) MSUD graft recipients: In 8 cases, HV reconstruction was performed between the graft's HV confluence and the recipient's HV confluence, and in 3 cases, a vena cava triangulation was necessary; 6 MSUD grafts required HV venoplasty. No VG were needed for HV reconstruction. VG were used for PV reconstructio...Continue Reading

References

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Citations

Aug 29, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Wolf O Bechstein, Andreas A Schnitzbauer
May 1, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco SpadaCarlo Dionisi-Vici
Jun 13, 2019·Genetics and Molecular Biology·Taiane Alves VieiraRoberto Giugliani
Mar 22, 2019·Reviews on Recent Clinical Trials·Francesco SantopaoloLeonardo Baiocchi
Nov 6, 2020·Therapeutic Advances in Gastroenterology·Guang-Peng ZhouZhi-Jun Zhu
May 18, 2021·Molecular Genetics and Metabolism Reports·Laura GuilderSaadet Mercimek-Andrews
Aug 28, 2021·Pediatric Transplantation·Vikram K RaghuGeorge V Mazariegos
Aug 30, 2021·Molecular Genetics and Metabolism·Jenny A GreigJames M Wilson
Dec 29, 2021·Cancer Metastasis Reviews·Lenka RossmeislováKatarína Smolková

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