DOMINO1, a member of a small plant-specific gene family, encodes a protein essential for nuclear and nucleolar functions

The Plant Journal : for Cell and Molecular Biology
S LahmyMartine Devic

Abstract

Arabidopsis embryos carrying the domino1 mutation grow slowly in comparison with wild type embryos and as a consequence reach only the globular stage at desiccation. The primary defect of the mutation at the cellular level is the large size of the nucleolus that can be observed soon after fertilization in the nuclei of both the embryo and the endosperm. The ultrastructure of mutant nucleoli is drastically different from wild type and points to a fault in ribosome biogenesis. DOMINO1 encodes a protein, which belongs to a plant-specific gene family sharing a common motif of unknown function, present in the tomato DEFECTIVE CHLOROPLASTS AND LEAVES (LeDCL) protein. Using a GFP protein fusion, we show that DOMINO1 is targeted to the nucleus. We propose that inactivation of DOMINO1 has a negative effect on ribosome biogenesis and on the rate of cell division.

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Citations

Jun 1, 2005·Nature Genetics·Tatsuo KannoAntonius J M Matzke
Apr 27, 2007·Nucleic Acids Research·Sophie FleurdépineCécile Bousquet-Antonelli
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·M MatzkeA J M Matzke
Sep 30, 2010·PloS One·Erwana HarscoëtLoïc Lepiniec
Nov 16, 2013·Nucleic Acids Research·Ingo EbersbergerEnrico Schleiff
Feb 3, 2005·The Plant Journal : for Cell and Molecular Biology·Vinciane TillemansPatrick Motte
Dec 11, 2014·Annual Review of Plant Biology·Marjori A MatzkeAntonius J M Matzke
Feb 24, 2015·Bioinformatics and Biology Insights·Stefan SimmEnrico Schleiff
Oct 17, 2017·The Plant Journal : for Cell and Molecular Biology·Thiruvenkadam ShanmugamSang-Bong Choi
Jan 30, 2018·Frontiers in Plant Science·Iwai Ohbayashi, Munetaka Sugiyama
Mar 29, 2020·Plant Cell Reports·Yuying ZhangXiansheng Zhang
Mar 20, 2020·Cell·Claire D McWhiteEdward M Marcotte

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